Research Article
Volume 7 Issue 8 - 2020
Entecavir for Treatment of Chronic HBV Infection, Real-Life Data from Saudi Arabia
Ghadah Musaad AlMutiri*, Khaled Bzeizi, Nasser Almasri, Abdullah Madani, Ali Albenmousa
Department of Internal Medicine, Prince Sultan Military Medical City, Saudi Arabia
*Corresponding Author: Ghadah Musaad AlMutiri, Department of Internal Medicine, Prince Sultan Military Medical City, Saudi Arabia.
Received: June 19,2020; Published: July 17, 2020




Abstract

Background: Chronic hepatitis B virus (HBV) infection is one of the most common causes of chronic liver disease worldwide. Untreated disease can lead to cirrhosis, hepatocellular carcinoma (HCC) and mortality in a significant proportion of affected patients. Two potent nucleotide(side) inhibitors (entecavir and tenofovir) are widely used to control HBV and subsequently prevent its complication. The efficacy and safety of entecavir have been assessed in several clinical and real-life trials in western countries however no data from Saudi Arabia and middle east region.

Objective: To assess the efficacy of entecavir in treatment of chronic HBV in Saudi Arabia where the predominant genotype is genotype D.

Patients and Methods: A retrospective chart review for HBV infected patients who were treated with entecavir between June 2008 and June 2015 in Prince Sultan Military Medical City was carried out. We included all HBV patients treated with entecavir whether naive or treatment exposed, e Ag positive and e Ag negative and cirrhotic and non cirrhotic patients. Patients with acute HBV infection were excluded. Relevant data were collected and analyzed descriptively and inferentially with SPSS version 17.

Conclusion: Entecavir is highly effective in controlling HBV infection in a large cohort of Saudi patients. It has an excellent safety profile and can be considered as one of the first line options for treatment of HBV infected cirrhotic and non cirrhotic patients.

Keywords: Hepatitis B Virus (HBV); Hepatocellular Carcinoma (HCC); Entecavir

References

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Citation: Ghadah Musaad AlMutiri., et al. “Entecavir for Treatment of Chronic HBV Infection, Real-Life Data from Saudi Arabia”. EC Gastroenterology and Digestive System 7.8 (2020): 105-110.

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