Research Article
Volume 7 Issue 8 - 2020
New Options in Management of Iron-Deficiency Syndromes in Inflammatory Bowel Diseases
NI Stuklov1,2*, IG Basiladze1,3, MS Kovalchuk1, AV Pivnik1,3, OV Knyazvev3, AI Parfenov3 and G Tarantino4
1Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia
2National Medical Research Radiological Center, Moscow, Russia
3Loginov Moscow Clinical Scientific Center, Moscow, Russia
4Pharmanutra Spa, Scientific Department, Pisa, Italy
*Corresponding Author: NI Stuklov, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia.
Received: May 15,2020; Published: July 17, 2020




Abstract

The article describes the most common iron deficiency syndromes (IDS) in inflammatory bowel disease (IBD) and presents the modern principles of differential diagnosis of gastrointestinal disease, the advantages and disadvantages of standard methods for the correction of iron-deficiency (ID) and anemia in this group of patients.

The authors give a circumstantial outline of their own data regarding the examination and treatment of 77 patients with IBD and anemia and prove the necessity of compulsory serum ferritin (SF) testing as the most important differential marker of the IDs. Inadequate production of erythropoietin as the main cause of anemia was observed in 15% of patients with high SF values. On the contrary, the necessity of mandatory use of iron preparations in management of anemia was determined in 85% of patients. The high effectiveness and safety of Sucrosomial® iron were proved in patients with IBD and anemia.

The effectiveness of this method showed the normalization of hemoglobin in 68% of patients within 3 months. In contrast, intravenous iron administered during the inpatient treatment period was not sufficiently effective in this category of patients, which required the continuation of outpatient therapy with preparations of Sucrosomial® iron.

Based on the obtained data and international experience, there was formulated and substantiated the algorithm of differentiated therapy of IDS in patients with a mild form of IBD.

Keywords: Iron Deficiency; Iron Deficiency Syndrome; Inflammatory Bowel Disease; Treatment of Anemia; Sucrosomial® Iron; Intravenous Iron

References

  1. Filmann N., et al. “Prevalence of anemia in inflammatory bowel diseases in European countries: a systematic re- view and individual data meta-analysis”. Inflammatory Bowel Diseases 20.5 (2014): 936-945.
  2. Testa A., et al. “The burden of anemia in patients with inflammatory bowel diseases”. Digestive and Liver Disease 48.3 (2016): 267-270.
  3. Cronin CC and Shanahan F. “Anemia in patients with chronic inflammatory bowel disease”. The American Journal of Gastroenterology 96 (2001): 2296-2298.
  4. Pizzi LT., et al. “Impact of chronic conditions on quality of life in patients with inflammatory bowel disease”. Inflammatory Bowel Disease 12 (2006): 47-52.
  5. Wilson A., et al. “Prevalence and outcomes of anemia in inflammatory bowel disease: a systematic review of the literature”. The American Journal of Medicine 116.7A (2004): 44S-49S.
  6. Gomollón F and Gisbert J. “Anemia and inflammatory bowel diseases”. World Journal of Gastroenterology 15.37 (2009): 4659-4665.
  7. Pratt JJ and Khan KS. “Non-anaemic iron deficiency - a disease looking for recognition of diagnosis: a systematic re- view”. European Journal of Haematology 96 (2016): 618-628.
  8. Vijverman A., et al. “Evolution of the prevalence and characteristics of anemia in inflammatory bowel diseases between 1993 and 2003”. Acta Gastro-Enterologica Belgica 69 (2006): 1-4.
  9. Dignass AU., et al. “European Crohnis and Colitis Organisation [ECCO]. European consensus on the diagnosis and management of iron deficiency and anemia in inflammatory diseases”. Journal of Crohn's and Colitis 9 (2015): 211-222.
  10. Uritski R., et al. “Dietary iron affects inflammatory status in a rat model of colitis”. Journal of Nutrition 134.9 (2004): 2251-2255.
  11. Goodnough LT and Nissenson AR. “Anemia and its clinical consequences in patients with chronic diseases”. The American Journal of Medicine (2004): 116.
  12. Rukavitsyn OA. “Anemia of chronic diseases: the important aspects of pathogenesis and treatment”. Oncohematology 11.1 (2016): 37-46.
  13. Gisbert JP and F Gomollon. “Common misconceptions in the diagnosis and management of anemia in inflamma- tory bowel disease”. The American Journal of Gastroenterology 103.5 (2008): 1299-1307.
  14. Chistyakova AV., et al. “Iron deficiency anemia diagnosis and treatment approaches in gastroenterological patients”. RMJ 13 (2015): 781-784.
  15. Auerbach M and Adamson JW. “How we diagnose and treat iron deficiency anemia”. American Journal of Hematology 91 (2016): 31-38.
  16. Cancelo-Hidalgo MJ., et al. “Tolerability of different oral iron supplements: a systematic review”. Current Medical Research and Opinion 29 (2013): 291.
  17. Gasché C., et al. “Anemia in Crohn’s disease. Importance of inadequate erythropoietin production and iron deficiency”. Digestive Diseases and Sciences 39 (1994): 1930-1934.
  18. Dignass AU., et al. “European consensus on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases”. Journal of Crohn's and Colitis 9.3 (2015): 211-222.
  19. Tobu M., et al. “Erythropoietin-induced thrombosis as a result of increased inflammation and thrombin activatable fibrinolytic inhibitor”. Clinical and Applied Thrombosis/Hemostasis 10 (2004): 225-232.
  20. Koutroubakis IE., et al. “Effectiveness of darbepoetin-alfa in combination with intravenous iron sucrose in patients with inflammatory bowel disease and refractory anaemia: a pilot study”. European Journal of Gastroenterology and Hepatology 18 (2006): 421-425.
  21. Kulnigg S and Gasche C. “Systematic review: managing anaemia in Crohn’s disease”. Alimentary Pharmacology and Therapeutics 24 (2006): 1507-1523.
  22. Tarantino G., et al. “Sucrosomial® Iron: A New Highly Bioavailable Oral Iron Supplement”. Blood 126 (2015): 4561.
  23. Abbati G., et al. “Safety and efficacy of sucrosomial iron in inflammatory bowel disease patients with iron deficiency anemia”. Intern Emerg Med 14.3 (2015): 423-431.
Citation: NI Stuklov., et al. “New Options in Management of Iron-Deficiency Syndromes in Inflammatory Bowel Diseases”. EC Gastroenterology and Digestive System 7.8 (2020): 94-104.

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