Review Article
Volume 5 Issue 8 - 2020
The Epidemiology of the Dysfunctional Microbiome in Animals and in Humans: The Propensity for the Development of Non-Communicable Disease
David Smith and Sohan Jheeta*
NoR CEL (Network of Researchers on the Chemical Evolution of Life), Leeds, UK
*Corresponding Author: Sohan Jheeta, NoR CEL (Network of Researchers on the Chemical Evolution of Life), Leeds, UK.
Received: May 30, 2020; Published: July 13, 2020




Abstract

There is a worldwide increase in the incidence of non-communicable disease associated with obesity, mental health and atopic disease, the latter also observed in animals. In earlier articles we suggested that the microbiome is a single mutualistic microbial community interacting with our body by two overlapping sets of semiochemicals: allomones that enable the microbiota to be fed by effective transfer of nutrition through the gut and kairomones somehow acting to calibrate animal immune systems so as to distinguish the harmless from the potentially harmful, such as pollen from pathogens. Non-communicable diseases arise as the microbiome loses vital functions, a variable state that has been termed dysbiosis and which may theoretically be assessed by measuring the formation of potential allomones such as dopamine and serotonin. This article attempts to shed light on these semiochemical processes by looking at the epidemiology of dysbiosis within both human and animal populations: who does it affect and when? As a possible example, the fate of English populations of the European hedgehog, Erinaceus europaeus is briefly considered. These ideas are discussed in the light of a startling new observation: that the mean body temperature of men and women in the United States has been decreasing by 0.03°C per birth decade for at least the last 150 years. Is the nature of our immune system changing from proactive to reactive?

Keywords: Atopic Disease; Body Temperature; Dysbiosis; European hedgehog; Growth Promoters; Gut-Brain Axis; Heavy Metal Poisoning; Holobiont; Ingestible Sensor; Mental Health; Microbiome; Non-Communicable Disease; Obesity; Tsimane

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Citation: David Smith and Sohan Jheeta. “The Epidemiology of the Dysfunctional Microbiome in Animals and in Humans: The Propensity for the Development of Non-Communicable Disease”. EC Gastroenterology and Digestive System 7.8 (2020): 83-93.

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