Volume 5 Issue 8 - 2018
Growing Multidrug Resistance of Helicobacter pylori to Antibiotics: an Alarm to Gastric Health
Rajesh N Gacche*
Professor, Department of Biotechnology, Savitribai Phule Pune University, Pune, Maharashtra, India
*Corresponding Author: Rajesh N Gacche, Professor, Department of Biotechnology, Savitribai Phule Pune University, Pune, Maharashtra, India.
Received: June 28, 2018; Published: July 05, 2018
Citation: Rajesh N Gacche. “Growing Multidrug Resistance of Helicobacter pylori to Antibiotics: an Alarm to Gastric Health”. EC Gastroenterology and Digestive System 5.8 (2018): 553-555.
Barry J. Marshall and Robin Warren, two Australian researchers established the identity of Helicobacter pylori (H. pylori) from the biopsies of human subjects suffering from chronic gastritis and gastric ulcers [1]. The discovery of this gram-negative, microaerophilic bacterium opened a new window in the mainstream of gastrointestinal research and made a paradigm shift in approaches of studying the gastrointestinal diseases. At least half the world’s population is infected by H. pylori, grading it one of the most widespread infection in the world. Over 50% of the world’s population have H. pylori infection in their upper gastrointestinal tract which perhaps may be associated with significant role in the gastric niche. Dramatically, over 80% of infected individuals remain asymptomatic. In general, the incidence of H. pylori infection is more common in developing countries than Western countries [2].
Interestingly, until the discovery of H. pylori, gastritis and gastric ulcers were not believed to have a microbial cause owing to the conventional thinking that no bacterium can sustain in the acidic environment of the human stomach. After discovery of this bacterium, a long debate continued about its identity and patho-physiological roles. Of note, to demonstrate the H. pylori as a causative agent of gastritis, Marshall drank a H. pylori containing solution, as result he became sick with symptoms like nausea and vomiting several days later. After 10 days inoculation, he underwent endoscopy analysis which revealed the signs of gastritis and the presence of H. pylori. Over two decades research of these two crazy researchers awarded the Nobel Prize of 2005 in Physiology or Medicine.
Luminescent conjugated poly- and oligothiophenes (LCPs and LCOs) are conformation-sensitive optical probes for amyloids that consists of swiveling thiophene backbone. These luminescent ligands have also been reported to specifically bind proteins with cross β-sheet conformation and have been established as a sensitive tool for prion strain differentiation.
Impressive repertoire of chemotactic and metabolic adaptive mechanisms has been identified in H. pylori for its survival abilities in acidic environment of stomach [3,4]. In the present state of the art, sizable preclinical and clinical literature has accumulated in the recent past linking the role of H. pylori in the development of duodenal ulcers and stomach cancer. Besides having a scope for further investigation, to a greater extent, it has now been partly accepted that H. pylori infection is the most important risk factor for the development of non-cardia gastric cancer [5]. More precisely, the transition from normal mucosa to non-atrophic gastritis is primarily induced by H. pylori infection which results into formation of precancerous lesions which may then advances to development of atrophic gastritis and intestinal metaplasia. However, further developments leading to gastric cancer are generally believed to be independent of H. pylori [6]. Besides the causing of gastritis and gastric ulcer, perhaps the link of H. pylori in progression of gastric cancer has accelerated the H. pylori research.
Copyright: © 2018 Rajesh N Gacche. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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