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Case Report
Volume 6 Issue 6 - 2021
Acute Transient Hyperglycaemia after COVID-19 Vaccination in Patients with Stable Diabetes
R Bhatti1*, S Adhami2, A H Khamis3 and G Matfin4
1Consultant Endocrinologist, Mediclinic City Hospital, Dubai, UAE
2Certified Diabetes Educator, Mediclinic City Hospital, Dubai, UAE
3Professor of Biostatistics, Mohammad Bin Rashid University of Medicine and Health Sciences, Dubai, UAE
4Consultant Endocrinologist, Mediclinic City Hospital and Professor of Medicine, Mohammad Bin Rashid University of Medicine and Health Sciences, Dubai, UAE
*Corresponding Author: R Bhatti, Consultant Endocrinologist, Mediclinic City Hospital, Dubai, UAE.
Received: August 24, 2021; Published: September 07, 2021


Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for causing the COVID-19 pandemic. Since effective COVID-19 vaccinations have become available worldwide, patients with diabetes are considered to be in the highest priority group to be vaccinated. To date, 3 vaccines are available in the UAE. These are the Pfizer-BioNTech, Sinopharm and Sputnik vaccines.

Objective: We describe 2 cases of patients who had diabetes with stable glycaemic control, who however, developed hyperglycaemia post COVID-19 vaccination.

Methods: Case presentation from a private hospital in Dubai of 2 patients with diabetes who were seen in ambulatory care setting regarding their glycaemic control.


Case 1:A 51-year-old Asian male, known to have type 2 diabetes, was reviewed in the ambulatory care setting following COVID-19 vaccination. His recent glycaemic control was stable with glycosylated haemoglobin (HbA1c) 3 months before presentation of 7.5%. His medications for diabetes included: xultophy injection (fixed-ratio combination of insulin degludec and liraglutide) 14 units at night, in addition to oral metformin 1000 mg twice daily. His history included ischaemic heart disease stable on medication. He took his first dose of Pfizer-BioNTech vaccine on 30th December 2020 followed by second dose 3 weeks later. All blood glucose levels (BG) pre-vaccination were within normal range. In contrast, post-COVID-19 2nd dose) fasting BG levels was elevated on Day 2 only. Similarly, evening pre-meal BG levels were elevated on Days 1, 4 and 6; with 2-hour post meal BG level also increased on Day 2. He was also asymptomatic during this period.

Case 2: A 30-year-old female, known type 1 diabetes, was reviewed in the ambulatory care setting following COVID-19 vaccination. She was on continuous subcutaneous insulin infusion (CSII) for her glycaemic control. Her HbA1c 3 months prior to presentation was 8.3%. She took her Sinopharm vaccination onth January 2021. Her continuous glucose monitoring (CGM) data shows time in range TIR of 68% one week before 1st dose of vaccination and it dropped to 66% one week after 1st dose of vaccination. Her TIR was 62% one week before 2nd dose and it dropped down to 40% week after 2nd dose. She was asymptomatic during this period.

Conclusion: The purpose of this case series is to make healthcare professionals aware of potential transient hyperglycaemia post- COVID-19 vaccination in patients with diabetes. We strongly recommend vaccination for people with diabetes as benefits far outweighs the risk. However, patients should be educated by their healthcare professional in advance for close blood glucose monitoring post vaccination and regarding sick-day rules. As ADA 2021 recommendations were developed before COVID-19 vaccines were available worldwide, no detailed information regarding COVID-19 vaccination is captured.

Keywords: Hyperglycaemia; Covid-19 Vaccination


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Citation: R Bhatti., et al. “Acute Transient Hyperglycaemia after COVID-19 Vaccination in Patients with Stable Diabetes”. EC Endocrinology and Metabolic Research 6.6 (2021): 33-38.

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