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Volume 6 Issue 6 - 2021
NLRP3 Inflammasome and Obesity: A Framework of Situation
Carmine Finelli1,2*
1Department of Internal Medicine, Ospedale Cav. R. Apicella - ASL Napoli 3 Sud, Via di Massa, Pollena, Napoli, Italy
2Covid Hospital Boscotrecase - ASL Napoli 3 Sud, Via Lenza, Boscotrecase, Napoli, Italy
*Corresponding Author: Carmine Finelli, Department of Internal Medicine, Ospedale Cav. R. Apicella - ASL Napoli 3 Sud, Via di Massa, Pollena, Napoli, Italy.
Received: August 24, 2021; Published: September 07, 2021


Obesity puts people at risk for a variety of IL-1-driven metabolic disorders, such as atherosclerosis and type 2 diabetes mellitus (T2D) [1]. Moreover, the activation of adipose tissue macrophages (ATMs) inside fat deposits has been associated to an obesity-induced inflammatory state [2]. Furthermore, a new study found that obesity promotes the NLRP3 inflammasome to assemble in ATMs, resulting in insulin resistance in early T2D patients [3]. Higher level of both NLRP3 and IL-1 in visceral adipose tissue in free-feeding mice on a conventional chow diet was observed to associate significantly with body weight and adiposity when matched to mice fed a calorie-restricted diet. Weight loss in obese T2D patients was linked to lower NLRP3 and IL-1β expression in subcutaneous adipose tissue, which was similar to the findings in mice. Gene-deficient mice fed a high fat diet demonstrated lower caspase-1 activation and pro-IL-1β expression in adipose tissue, as well as a loss in serum IL-18 synthesis, compared to their wildtype counterparts. Furthermore, NLRP3- and caspase-1-deficient animals are more resistant to insulin resistance caused by a high-fat diet [3,4]. Insulin sensitivity was observed to be reduced as a result of NLRP3 inflammasome-mediated activation of effector adipose T cells, which then mediate downstream insulin resistance pathways via releasing interferon-gamma [5].


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Citation: Carmine Finelli. “NLRP3 Inflammasome and Obesity: A Framework of Situation”. EC Endocrinology and Metabolic Research 6.6 (2021): 25-27.

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