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Research Article
Volume 6 Issue 5 - 2021
Assessment of Decrease in Renal Function Associated with Hypothyroidism
Ayesha Ammar1*, Naseer Ahmed1, Kehkashan Bashir1, Sadaf Batool1, Maryam Syed2, Adnan Saeed1, M Faheem1 and Shazia Fatima1
1Pakistan Atomic Energy Cancer Hospital Noriaech, NORI, Islamabad, Pakistan
2Shifa College of Medicine, Islamabad, Pakistan
*Corresponding Author: Ayesha Ammar, Senior Medical Officer, Pakistan Atomic Energy Cancer Hospital Noriaech, NORI, Islamabad, Pakistan.
Received: April 16, 2021; Published: April 30, 2021


Objective: Study was aimed to see the effects of hypothyroidism on GFR as a renal function.

Materials and Methods: Total of fifty eight patients was included in the study. Out of those forty eight patients were female and twelve were male. They were divided into 2 groups. Group 1 consists of Fifty three patients who were known case of thyroid cancer in which hypothyroidism was due to discontinuation of thyroxine before the administration of radioactive iodine for Differentiated thyroid cancer. Group 2 consists of five patients were post radioactive iodine treatment (for hyperthyroidism) hypothyroid.

Inclusion Criteria: All of the patients were above eighteen years of age with TSH value > 30 µIU/ml. Pregnant and lactating females were excluded. Blood samples for urea, creatinine, creatinine clearance and serum electrolytes were taken followed by Tc-99m-DTPA renal scan for GFR assessment (GATES’ method) were carried out in all subjects twice during the study, One study during hypothyroid state (TSH > 30 µIU/ml) and other during euthyroid state (TSH between 0.4 to 4µ IU/ml). The results of Student’s t-test showed significant difference in renal functions (Urea, creatinine, creatinine clearance, GFR values) in euthyroid state and hypothyroid state (p-value < 0.05).

Results: In case of creatinine the paired t test reveal the mean 1.014 ± 0.428, with standard error of 0.669 within 95% confidence interval, for creatinine clearance 80.11 ± 14.12 with standard error of 1.94 within 95% confidence intervals, for urea the mean 28 ± 12.13 with standard error of 1.607 within 95% confidence intervals and for GFR for individual kidney is 38.056 ± 8.56 with standard error of 1.3717 within 95% confidence interval.

Conclusion: Hypothyroidism impairs renal function to a big level and hence must be prevented and corrected as early as possible.


Keywords: Thyroid Dysfunction; G.F.R; Cancer Thyroid; Hyperthyroidism


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Citation: Ayesha Ammar., et al. “Assessment of Decrease in Renal Function Associated with Hypothyroidism”. EC Gastroenterology and Digestive System 6.5 (2021): 01-12.

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