Conceptual Paper
Volume 6 Issue 3 - 2021
Adenosine Deaminase and its Role in Diabetes Mellitus Type 2:
Possible Marker of Insulin Resistance?
1Clinical Analysis Postgraduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro (RJ), Brazil
2Department of Pathology, Faculty of Medicine, UFF, Niterói, RJ, Brazil
*Corresponding Author: Luciene de Carvalho Cardoso Weide, Department of Pathology, Faculty of Medicine, UFF, Niterói, RJ, Brazil.
Received: February 23, 2021; Published: February 27, 2021
Adenosine deaminase (ADA) is a ubiquitously expressed enzyme, found in the cytosol where it catalyzes the irreversibly deamination of adenosine (deoxyadenosine) into inosine (deoxyinosine), in the purine pathway. ADA expression and activity is vital for the metabolism of purines, regulating the concentration of adenosine through the deamination process [1,2]. Absent or deficient ADA activity leads to the accumulation of the enzyme substrates, such as deoxyadenosine, which is a toxic metabolite related to the inhibition of DNA synthesis [3].
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Citation: Karina Costa Coelho Gonçalves and Luciene de Carvalho Cardoso Weide. “Adenosine Deaminase and its Role in Diabetes Mellitus Type 2: Possible Marker of Insulin Resistance?”. EC Endocrinology and Metabolic Research 6.3 (2021): 39-41.
Copyright: © 2021 Karina Costa Coelho Gonçalves and Luciene de Carvalho Cardoso Weide. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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