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Research Article
Volume 6 Issue 2 - 2021
Impact of a Cinnamon Extract Vs. Placebo on Metabolic Control in Patients with Type 2 Diabetes Mellitus
Pfützner A1,2*, Drexel H3,4, Grafinger P5, Hoppichler F6, Ludvik B7, Prager R8, Wascher TC9, Schnell O10 and Weitgasser R11,12
1Pfützner Science and Health Institute, Mainz, Germany
2Institute for Internal Medicine and Laboratory Medicine, University for Digital Technologies in Medicine and Dentistry, Wiltz, Luxembourg
3VIVIT Institute, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
4Private University of the Principality of Liechtenstein, Triesen, Liechtenstein
5Department of Internal Medicine 2, Kepler University Hospital, Linz, Austria
6Department of Internal Medicine, Barmherzige Brüder Hospital, Salzburg, Austria
7Department of Internal Medicine 1, Rudolfstiftung Hospital, Vienna, Austria
8Karl Landsteiner Institute for Metabolism and Nephrology, Vienna, Austria
9Department of Internal Medicine 1, Hanusch Hospital, Vienna, Austria
10Institute for Diabetes Research, Munich, Germany
11Department of Internal Medicine/Diabetology, Wehrle-Diakonissen Hospital, Salzburg, Austria
12Department of Internal Medicine 1, University Hospital Salzburg, Salzburg, Austria
*Corresponding Author: Pfützner A, Pfützner Science and Health Institute, Mainz, Germany and Institute for Internal Medicine and Laboratory Medicine, University for Digital Technologies in Medicine and Dentistry, Wiltz, Luxembourg.
Received: December 21, 2021; Published: January 30, 2021


Background: Cinnamon preparations have been shown to reduce blood glucose and improve HbA1c in patients with Type 2 Diabetes mellitus. However, some meta-analyses have resulted in inconclusive data due to the heterogeneity of materials and patients in various published trials. In order to evaluate the effects of a cinnamon extract preparation on metabolic control, we performed a double-blind randomized placebo-controlled prospective study with a cinnamon extract from Cinnamomum aromaticum (C. cassia).

Subjects/Methods: We included 109 patients with type 2 diabetes and suboptimal glycemic control (HbA1 ≥ 7.0). Patients were randomized to receive one capsule daily containing 314 mg of cinnamon extract or placebo for four months on top of their regular treatment. Observation parameters were changes in HbA1c, HOMA-IR, hsCRP, adiponectin and lipids.

Results: HbA1c improved from 7.92 ± 0.98% to 7.39 ± 0.98% in the cinnamon group (-7%, p < 0.005) and from 7.73 ± 0.80% to 7.44 ± 0.94% in the placebo group (-3.8%; p < 0.05). Significant differences in favour of the cinnamon intervention were seen for almost all indicators of insulin resistance, inflammation and lipid distribution. Both treatments were well tolerated.

Conclusion: We found a consistent improvement in markers of glycaemic control, chronic systemic inflammation and insulin resistance during supplementation with cinnamon extract in comparison to further deteriorations with placebo. These results support the use of cinnamon extracts as dietary supplement for patients with type 2 diabetes and metabolic syndrome.

Keywords: Cinnamomum; Cinnamon; Type 2 Diabetes and Metabolic Syndrome


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Citation: Pfützner A., et al. “Impact of a Cinnamon Extract Vs. Placebo on Metabolic Control in Patients with Type 2 Diabetes Mellitus”. EC Endocrinology and Metabolic Research 6.2 (2021): 32-42.

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