Research Article
Volume 5 Issue 10 - 2020
A Strong, Rectangular Hyperbolic Relationship Links the I0*G60 with the Matsuda-Defronzo’s Insulin Sensitivity Index
Patricio H Contreras1,2*, Yanara A Bernal2and Pilar Vigil1,2,3
1Fundación Médica San Cristóbal, Santiago, Chile
2Reproductive Health Research Institute (RHRI), Santiago, Chile
3Vicerrectoría de Comunicaciones, Pontificia Universidad Católica de Chile, Santiago, Chile
*Corresponding Author: Patricio H Contreras, Fundación Médica San Cristóbal, Santiago, Chile.
Received: September 17, 2020; Published: September 24, 2020




Abstract

In a previous work of our group the “I0*G60” -a novel predictor of Insulin Resistance (IR)-, was found when we performed a ROC analysis of several biochemical predictors of IR, including the Matsuda-DeFronzo’s Insulin Sensitivity Index test, ISI) against the Pancreatic Suppression Test (PST). ROC analysis defined the optimal diagnostic cut-offs of several biochemical predictors of IR, including the ISI. The I0*G60 is the product of the I0 (fasting serum insulin value) times the G60 (serum glucose value at 60 minutes of the OGTT). In 90 subjects having both a PST and an OGTT, the I0*G60 outperformed all the studied predictors of IR. The ISI value was calculated in Matsuda's webpage (ISI-OL). The I0*G60 and the ISI-OL were linearly correlated (r = -0.627). In this work, we plotted the I0*G60 against the ISI-OL in the initial cohort of 90 subjects. The graph was highly suggestive of a rectangular hyperbolic relationship between these two predictors. We, therefore, modelled the relationship as a non-linear regression and obtained an equation describing the I0*G60-based prediction of the ISI-OL: ISI-OL = parameter1* “I0*G60” ^ parameter2. The non-linear determination coefficient (r2) was 0.899. We repeated the procedure with a total of 831 pair of values. The linear correlation coefficient between these variables was -0.573. The resulting graph was again highly suggestive of a rectangular hyperbolic relationship. The modelling produced the final predictive equation: ISI-OL = 782.7 * “I0*G60” ^ - 0.744. The determination coefficient (r2) was 0.822. We conclude that the main reason for the excellent performance of the I0*G60 resides in its ability to accurately predict the ISI-OL value.

Keywords: Predictors of Insulin Resistance; ISI-Composite; I0*G60; Hyperbolic Rectangular Relationship

References

  1. DeFronzo RA., et al. “Glucose clamp technique: a method for quantifying insulin secretion and resistance”. American Journal of Physiology 3 (1979): E214-E223.
  2. Shen S-W., et al. “Comparison of impedance to insulin-mediated glucose uptake in normal subjects and subjects with latent diabetes”. Journal of Clinical Investigation 12 (1970):2151-2160.
  3. Kim MK., et al. “Hyperinsulinemia in individuals with obesity: role of insulin clearance”. Obesity (Silver Spring) 12 (2015): 2430-2434.
  4. Vigil P., et al. “Evidence of subpopulations with different levels of insulin resistance in women with polycystic ovary syndrome”. Human Reproduction 11 (2007): 2974-2980.
  5. Contreras PH., et al. “Insulin sensitivity and testicular function in a cohort of adult males suspected of being insulin-resistant”. Frontiers in Medicine 190 (2018): 1-9.
  6. Greenfield MS., et al. “Assessment of insulin resistance with the insulin suppression test and the euglycemic clamp”. Diabetes5 (1981): 387-392.
  7. Knowles JW., et al. “Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp”. Metabolism4 (2013): 548-553.
  8. Garmendia ML., et al. “Valores normativos de resistencia a la insulina mediante HOMA-IR en adultos mayores de Santiago de Chile”. Revista Médica De Chile 137 (2009): 1409-1416.
  9. Salgado AM., et al. “Estudio crítico del HOMA como método de pesquisa de resistencia insulínica en clínica”. Revista Chilena de Endocrinología y Diabetes 2 (2008).
  10. Matsuda M and DeFronzo RA. “Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp”. Diabetes Care9 (1999): 1462-1470.
  11. Contreras PH., et al. “A simple and improved predictor of insulin resistance extracted from the oral glucose tolerance test: the I0*G60”. Journal of the Endocrine Society 6 (2019): 1154-1166.
  12. Contreras PH., et al. “The I0*G60, a New Kid on the Block”. EC Endocrinology and Metabolic Research2 (2020): 01-06.
  13. Knopp JL., et al. “Insulin Units and Conversion Factors: A Story of Truth, Boots, and Faster Half-Truths”. Journal of Diabetes Science and Technology3 (2019): 597-600.
Citation: Patricio H Contreras., et al. “A Strong, Rectangular Hyperbolic Relationship Links the I0*G60 with the Matsuda-Defronzo’s Insulin Sensitivity Index”. EC Endocrinology and Metabolic Research 5.10 (2020): 09-14.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


November Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and can be viewed in the current issue pages.

Submission Deadline for January Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the January issue of respective journals. Submissions are accepted on/before December 12, 2020.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk