Abstract

The increasing incidence of diabetes is a major health issue The detection and management of prediabetes can delay the onset of diabetes. For that, we conducted a systematic electronic database search for relevant studies published from inception and till 30th May 2020 in seven databases. Finally, we included 47 studies in this systematic review. Screening for pre-diabetes should be considered in asymptomatic adults, at any age, with body mass index (BMI) ≥ 25 kg/m2 (Asian Americans: ≥ 23 kg/m2) with one or more of diabetes risk factors, women with gestational diabetes mellitus, and all patients aged ≥ 45 years. It should be also done in children and adolescents following the puberty onset or > 10 years of age, whichever earlier, if their BMI ≥ 85th percentile and have one or more of diabetes risk factors. The mainstay of lifestyle interventions is to adjust the modifiable risk factors such as increasing physical activity, promoting a healthy diet, and weight reduction. However, the health care workers showed substantial resistance to maintaining lifestyle counseling in the long term. Multiple treatment options have been tried in the context of prediabetes; including antidiabetics or non-antidiabetics; however, Metformin sounds to be the best candidate. In conclusion, an integrated system of prediabetes screening and management in different care settings is highly recommended.

Keywords: Prediabetes; Screening; Lifestyle Intervention; Metformin

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