Pancreas produces digestive enzymes and hormones to control blood glucose balance in the body. This comprises of two segments. Exocrine tissue includes acinar cells and ductal system to carry the digestive juice till duodenum. Surrounded inside the exocrine tissues exist in extremely organized well-made elements called islets of Langerhans in which the five hormone secreting cells are assembled. A highly structured molecular program which is complex to regulate the allocation of cell progenitors towards mature endocrine cells during mouse pancreas genesis [1-4].

At the 13.5^th embryonic day of gestation secondary transition occurs where pancreatic epithelium undergoes growth, branching and differentiation whereas on the 12.5^th day of gestation fusion of ventral and dorsal pancreas take place. Multipotent progenitor cells marked by the expression of Pdx1, Ptf1a, Cpa1, and c-myc be present in tip of the branching epithelium which is seen through the Genetic lineage tracing experiments [5]. After the 14^th gestational day the t progenitors separate as acinar, duct, and endocrine cell to finally limited to exocrine face [6,7].

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