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Review Article
Volume 5 Issue 4 - 2020
Regeneration of Pancreas Gland
Maria Lúcia D’Arbo Alves*
Medicine Course, Universidade de Ribeirão Preto, São Paulo, Brazil
*Corresponding Author: Maria Lúcia D’Arbo Alves, Medicine Course, Universidade de Ribeirão Preto, São Paulo, Brazil.
Received: March 03, 2020; Published: March 31, 2020


Diabetes mellitus is a hyperglycemic syndrome characterized by a reduced production of insulin or of insulin action and a relative or absolute increase of glucagon, the main insulin counterregulatory hormone. The disease courses with mutilating chronic complications. The inability to produce or to respond to insulin, a hormone synthesized by pancreatic β-cells, leads to diabetes. There is an excruciating need of finding new approaches to protect or restore these cells once they are lost. The first rudimentary attempt to transplant the pancreas occurred in 1894 before insulin was isolated by Banting, Best and Collip in 1921. Current research is focusing on β-cell regeneration in the human pancreas, this probably being one of the most controversial aspects of research on DM1. As a more general definition, we may state that β-cell regeneration corresponds to the formation of new β-cells whether or not these cells were actually lost. The potential mechanisms of β-cell regeneration are the proliferation of these specific cells, their neogenesis from non-β-cell precursors, and their trans-differentiation from α-cells. There are favorable and unfavorable arguments regarding the ability of the human pancreas to regenerate β-cells within the context of DM1 and in other pathological conditions such as resections, fibrocystic disease and neoplasia. The enigma continues regarding whether the function of β-cells persists in diabetic patients through regeneration or neogenesis maintained in T1D. In this paper we discuss the history of Diabetes knowing from Insulin Discovery until α- cell transdifferentiating.

Keywords: Regeneration; Trans Differentiation; Beta-Cell; Pancreas Islet; Pancreas Gland


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Citation: Maria Lúcia D’Arbo Alves. “Regeneration of Pancreas Gland”. EC Endocrinology and Metabolic Research 5.4 (2020): 32-37.

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