Research Article
Volume 5 Issue 4 - 2020
Oxidative Stress and Antioxidant Status in Preeclampsia
Vinay M, Jisha KR, Kathiresan V and Sheriff DS*
Department of Biochemistry, Reprolabs, Chennai, India
*Corresponding Author: Sheriff DS, Department of Biochemistry, Reprolabs, Chennai, India.
Received: February 28, 2020; Published: March 17, 2020


Introduction and Aim: Pre-eclampsia is a pregnancy specific hypertensive condition with marked proteinuria. 3 to 10% of pregnancies are associated with pre-eclampsia. One of the causes that are related to pre-eclampsia is reported to be oxidant stress. Therefore, in the present study oxidant stress in pre-eclampsia is studied.

Materials and Methods: A case-control study was performed on 45 pregnant women with preeclampsia as cases and 30 normal pregnant women as controls, all at term (37 to 40 gestational weeks). The diagnosis of pre-eclampsia was based on the definition of American College of Obstetrics and Gynecologists.

Serum glutathione peroxidase (GPX) and superoxide dismutase (SOD), malondialdehyde (MDA) and Vitamin E were measured in the control as well as in pregnant women with pre-eclampsia. Routine standard methods were used to measure the parameters studied and subjected to relevant statistical analyses.

Results: The levels of oxidative stress markers GPX, SOD, and MDA in the controls and cases were shown in table 2. The antioxidant enzyme GPx and SOD were increased in the pregnant women with pre-eclampsia compared to the control subjects. MDA levels are also significantly increased in the pregnant women with pre-eclampsia. cases studied.

Conclusion: The preliminary study indicates that oxidant stress could be one of the factors that cause endothelial injury and may induce hypertension in pre-eclampsia.

Keywords: Pre-eclampsia; Pregnancy; Oxidant Stress; Antioxidant Enzymes; MDA


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Citation: Sheriff DS., et al. “Oxidative Stress and Antioxidant Status in Preeclampsia”. EC Endocrinology and Metabolic Research 5.4 (2020): 16-19.

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