Research Article
Volume 5 Issue 4 - 2020
Glycemic Profile of Indian Patients Receiving Hydroxychloroquine
Mohamed Iliyas1,2*, Sundaramurthy Ganesan2, Rajeswari Sankaralingam3 and Alagu Thiyagarajan4
1Institute of Cardiology, Madras Medical College, Chennai, India
2Institute of Internal Medicine, Madras Medical College, Chennai, India
3Department of Rheumatology, Shri Ramachandra Medical College and Research Institute, Chennai, India
4Department of General Medicine, Coimbatore Medical College, Coimbatore, India
*Corresponding Author: Mohamed Iliyas, Institute of Cardiology and Institute of Internal Medicine, Madras Medical College, Chennai, India.
Received: March 04, 2020; Published: March 17, 2020




Abstract

Background and Aims: Hydroxychloroquine (HCQ) is a Disease Modifying Antirheumatic Drug (DMARD) known to produce hypoglycemia, widely used in Rheumatology. The anti-diabetic and anti-atherosclerotic effects of HCQ is a novel area of interest. The aim of this study was to identify the effect of hydroxychloroquine on blood glucose levels in Indian patients with rheumatological diseases.

Material and Method: A prospective observational study was conducted in the Institute of Rheumatology, Madras Medical College. 100 successive patients newly diagnosed with a rheumatological disease were selected. Baseline Glycated hemoglobin (HbA1c), fasting and postprandial blood sugar levels were measured and compared after 3 months of treatment with Hydroxychloroquine at a dose of 200 mg once daily. Efficacy was assessed by the changes in HbA1c, fasting and postprandial blood glucose levels after 3 months. Based on the results they were classified as diabetes mellitus (DM), impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) as recommended by American Diabetes Association [1]. The results were analyzed by paired t test.

Results: Out of 100 cases, 30 cases (30%) fell into DM group, 30 cases (30%) in IGT and 40 cases (40%) in NGT. In the DM group pre and post HCQ HbA1c levels were 6.75% and 6.39%, in the IGT group it was 6.24% and 5.95% while in the NGT group it was 6.24% and 5.95% respectively.

Conclusion: Hydroxychloroquine had greater effect in decreasing blood glucose level in patients with Diabetes Mellitus compared to those with Impaired and Normal glucose tolerance.

Keywords: Diabetes Mellitus; Glycated Hemoglobin; Hydroxychloroquine; Rheumatoid Arthritis; Systemic Lupus Erythematosus

References

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Citation: Mohamed Iliyas., et al. “Glycemic Profile of Indian Patients Receiving Hydroxychloroquine”. EC Endocrinology and Metabolic Research 5.4 (2020): 09-15.

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