Case Report
Volume 3 Issue 3 - 2018
An Adolescent with Prolactinoma or Factitious Hyperprolactinemia: Role of
Laboratory Immunoassay
1Department of Pediatrics, Division of Pediatric Endocrinology, New York University School of Medicine, New York, NY, USA
2Department of Pathology, New York University School of Medicine, New York, NY, USA
*Corresponding Author: Bina Shah, Department of Pediatrics, Division of Pediatric Endocrinology, New York University School of Medicine, New York, NY, USA.
Received: July 14, 2018; Published: August 01, 2018
Citation: Bina Shah., et al. “An Adolescent with Prolactinoma or Factitious Hyperprolactinemia: Role of Laboratory Immunoassay”. EC Endocrinology and Metabolic Research 3.3 (2018): 119-123.
Abstract
Introduction:Immunoassays, particularly when immunometric, may show falsely low/elevated levels due to interference from nonspecific antibodies in the serum [1].
Case Description:A 13 year old male evaluated for short stature was found to have elevated serum prolactin (PRL) 101.8 ng/mL (5 -
18 ng/mL) and FSH levels 61.1 mIU/mL (1.6 - 9.7 mIU/mL). Brain MRI showed a 3 mm microadenoma. The PRL level remained high
despite being on Cabergoline, with good compliance, for 3 months. Factitious hyperprolactinemia due to interfering antibodies (HA)
was suspected.
The serum sample was re-analyzed using 1. Serial dilution with the same analyzers 2. Heterophile blocking tube (HBT, Scantibodies)
and non-specific antibody blocking tube (NABT, Scantibodies) 3. Different platforms in reference lab ARUP (prolactin on the
ADVIA Centaur and FSH on the Roche COBAS). The results confirmed our suspicion.
Conclusion:It is important to look for interfering antibodies when the clinical picture does not correspond to the lab findings, to avoid unnecessary investigations and treatments.
Keywords: Heterophile Antibodies; Non-Specific Antibodies; Interfering Antibodies; Factitious Hyperprolactinemia
Copyright: © 2018 Bina Shah., et al This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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