Case Report
Volume 3 Issue 3 - 2018
An Adolescent with Prolactinoma or Factitious Hyperprolactinemia: Role of Laboratory Immunoassay
Misha Sodhi1, Janell Carter2, Lauren McVoy2, Manish Raisingani1, Raphael David1 and Bina Shah1*
1Department of Pediatrics, Division of Pediatric Endocrinology, New York University School of Medicine, New York, NY, USA
2Department of Pathology, New York University School of Medicine, New York, NY, USA
*Corresponding Author: Bina Shah, Department of Pediatrics, Division of Pediatric Endocrinology, New York University School of Medicine, New York, NY, USA.
Received: July 14, 2018; Published: August 01, 2018
Citation: Bina Shah., et al. “An Adolescent with Prolactinoma or Factitious Hyperprolactinemia: Role of Laboratory Immunoassay”. EC Endocrinology and Metabolic Research 3.3 (2018): 119-123.
Abstract
Introduction:Immunoassays, particularly when immunometric, may show falsely low/elevated levels due to interference from nonspecific antibodies in the serum [1].
Case Description:A 13 year old male evaluated for short stature was found to have elevated serum prolactin (PRL) 101.8 ng/mL (5 - 18 ng/mL) and FSH levels 61.1 mIU/mL (1.6 - 9.7 mIU/mL). Brain MRI showed a 3 mm microadenoma. The PRL level remained high despite being on Cabergoline, with good compliance, for 3 months. Factitious hyperprolactinemia due to interfering antibodies (HA) was suspected.
The serum sample was re-analyzed using 1. Serial dilution with the same analyzers 2. Heterophile blocking tube (HBT, Scantibodies) and non-specific antibody blocking tube (NABT, Scantibodies) 3. Different platforms in reference lab ARUP (prolactin on the ADVIA Centaur and FSH on the Roche COBAS). The results confirmed our suspicion.
Conclusion:It is important to look for interfering antibodies when the clinical picture does not correspond to the lab findings, to avoid unnecessary investigations and treatments.
Keywords: Heterophile Antibodies; Non-Specific Antibodies; Interfering Antibodies; Factitious Hyperprolactinemia
Copyright: © 2018 Bina Shah., et al This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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