Research Article
Volume 4 Issue 1 - 2020
Tumor Lysis Syndrome Associated with Breast Cancer, a Previously Unrecognized Oncologic Emergency
Britney Bell2 and Jue Wang1,2,3**
1Creighton University School of Medicine, USA
2St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA
3University of Arizona Cancer Center at Dignity Health St. Joseph’s Hospital and Medical Center, USA
*Corresponding Author: Jue Wang, Professor of Medicine, University of Arizona Cancer Center at Dignity Health St. Joseph’s, Phoenix, AZ, USA.
Received: November 09, 2019; Published: December 06, 2019


Background: Tumor lysis syndrome is a common oncologic emergency which has been well documented in patients suffering from hematologic malignancies. However, it is rarely reported in patients with solid tumors, even more rarely in patients with breast cancer. Many emergency room physicians, internists, even oncologists are not aware that TLS can actually occur in breast cancer. The objective of this study was to investigate the clinical characteristics and outcomes of TLS, a rare but life-threatening complication in breast cancer.

Methods: Retrospective literature review and pooled analysis.

Results: Twenty cases of TLS were identified in patients with breast cancer (19 case in published literature and 1 additional case from our tumor registry). The median age of patients was 57 years (31 - 94) with a female to male ratio of 19:1. All patients had extensive metastatic disease at the time of presentation, with visceral metastases documented in 100% of TLS cases. The in hospital mortality rate of entire cohort was 68%. The mortality rate for the patients developing treatment related TLS and spontaneous TLS were 50% and 75% respectively.

Conclusion: TLS in breast cancer can occur both after treatment and spontaneously and is associated with very high mortality. Our findings underscore the importance of heightened awareness, risk assessment and early prevention of this previously under-recognized oncologic emergency.

Keywords: Breast Cancer; Tumor Lysis Syndrome (TLS); Oncologic Emergency; Mortality


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Citation: Britney Bell and Jue Wang. “Tumor Lysis Syndrome Associated with Breast Cancer, a Previously Unrecognized Oncologic Emergency”. EC Emergency Medicine and Critical Care 4.1 (2020): 01-05.

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