Review Article
Volume 4 Issue 2 - 2020
Myasthenia Gravis: Trend of Therapeutic Agents in the Management of the Disease
Chika J Mbah*
Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
*Corresponding Author: Chika J Mbah, Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.
Received: December 22, 2019; Published: January 08, 2020




Abstract

Myasthenia gravis (MG) is an autoimmune disease caused by autoantibodies against the nicotinic acetylcholine receptors on the postsynaptic membrane at the neuromuscular junction. It is characterized by weakness and fatigability of the voluntary muscles. The objective of the study was to provide the trend of therapeutic agents utilized in the treatment of myasthenia gravis. The methodology utilized published works in scientific journals, official books and other medical and pharmaceutical relevant books to gather relevant information. Academic institution library as well as the internet websites offered assistance in the information gathering. The results have shown that the trend of these therapeutic agents against myasthenia gravis is acetylcholinesterase inhibitors, corticosteroids, immunosuppressants and immunomodulators and new chemical entities awaiting approval. The study suggests that drug treatment of myasthenia gravis is highly successful and has in combination with other treatment procedures very significantly reduced the mortality of patients with myasthenia gravis to near zero.

Keywords: Myasthenia Gravis (MG); Autoimmune Disease; Neuromuscular Junction (NMJ)

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Citation: Chika J Mbah. “Myasthenia Gravis: Trend of Therapeutic Agents in the Management of the Disease”. EC Emergency Medicine and Critical Care 4.2 (2020): 01-06.

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