Research Article
Volume 6 Issue 4 - 2022
Seroprevalence TTI’s (Transfusion Transmitted Infections) Hepatitis C, Hepatitis B and Human Immunodeficiency Virus, VDRL and Malaria in Blood Donors of Peshawar KPK, Pakistan
Hafsa Shah1*, Zia ur Rahman2, Mudassir Khan3, Fakhar Zaman4 and Shahid Badshah5
1CECOS University, Peshawar, Pakistan
2Center of excellence in Molecular Biology, Punjab University, Lahore, Pakistan
3Department of Healthcare Biotechnology, Atta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST), Islamabad, Pakistan
4Frontier Foundation Peshawar, Pakistan
5Regional Blood Center Peshawar, Pakistan
*Corresponding Author: Hafsa Shah, Department of Biotechnology, CECOS University of IT and Emerging Sciences, Peshawar, Pakistan.
Received: November 27, 2021; Published: March 30, 2022




Abstract

The goal of the study was to investigate the sero-prevalence of transfusion-transmitted infections (Hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), syphilis, and malarial parasite (MP) among voluntarily blood donors in Khyber Pakhtunkhwa (KPK), Pakistan. It is retrospective single centre cross sectional study. This study has been conducted from June 2020 to September 2021 (16 months) at the frontier foundation thalassemic center Peshawar KPK. Donors were physically healthy and were fit for donation. Donors with physical disabilities and/or having co-morbid conditions were excluded from the report. All of the samples were screened for anti-HIV, anti-HCV, HBsAg, Syphilis and Malarial Parasite via ELISA kit and Immunochromatographic Technique (ICT), respectively.), A total of 6311 blood donations were evaluated. Majority of the donations (92%) were from (VNRBD) voluntary non-remunerated blood donation, while only 8% came off the replacement donors. Amongst these donations, 95 were infected at least with one pathogen, while 6216 were cleared for transfusion; among which HBV positive cases were 0.855% (n = 54), HCV positive cases were 0.316% (n = 20), syphilis positive were 0.30% (n = 19) and MP positive cases were only 0.031% (n = 2). HBV, HCV, and syphilis infections rates were increased while little changes were observed in the malaria infections rates, and no case was reported for HIV. The study also revealed the distribution pattern of the aforementioned pathogens in blood groups of the reactive samples. RH+ve phenotype has the highest frequency of positive cases. Blood group A+ve has HBV 25.92% (14/54), HCV 40% (8/20), VDRL 10.52% (2/19), MP 50% (1/2) followed B+ve has HBV 35.1% (19/54), HCV 30% (6/20), VDRL 42.1% (8/19) and blood group O+ve has HBV 29.62% (16/54), HCV 15% (3/20), VDRL 21.05% (4/19) while blood group AB+ve has HBV 7.40% (4/54), HCV 15% (3/20), VDRL 26.3% (5/19) positive cases.

Keywords: HIV; HCV; HBV; Transfusion Transmitted Diseases; Infections; Syphilis; MP; ELISA; Blood Group

References

  1. https://www.who.int/news-room/fact-sheets/detail/blood-safety-and-availability
  2. Ehsan H., et al. “A Systematic Review of Transfusion-Transmissible Infections Among Blood Donors and Associated Safety Challenges in Pakistan”. Journal of Blood Medicine 11 (2020): 405.
  3. Arshad A., et al. “Prevalence of transfusion transmissible infections in blood donors of Pakistan”. BMC Hematology1 (2016): 27.
  4. Apata IW., et al. “Progress toward prevention of transfusion-transmitted hepatitis B and hepatitis C infection—sub-Saharan Africa, 2000-2011”. MMWR: Morbidity and Mortality Weekly Report29 (2014): 613.
  5. American Association of Blood Banks. Technical Manual/American Association of Blood Banks. AABB (2005).
  6. Saqlain N., et al. “BLOOD DONATION”. The Professional Medical Journal12 (2017): 1806-1811.
  7. Ali M., et al. “Hepatitis B virus in Pakistan. a systematic review of prevalence, risk factors, awareness status and genotypes”. Virology Journal1 (2011): 1-9.
  8. Mehr MT., et al. “Frequency of hepatitis B & C infection in newly recruited civil servants in Khyber Pakhtunkhwa”. Khyber Medical University Journal2 (2013).
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721999/
  10. Mehr MT., et al. “Frequency of hepatitis B & C infection in newly recruited civil servants in Khyber Pakhtunkhwa”. Khyber Medical University Journal2 (2013).
  11. Shah SZ., et al. “Sero-Prevalence of HCV and HIV antibodies among different groups of general population of Peshawar Cantonment, KPK, Pakistan” (2015).
  12. World Hepatitis Day 2018 global.
  13. Mehmood S., et al. “National prevalence rate of hepatitis B and C in Pakistan and its risk factors”. Journal of Public Health 28 (2019): 751-764.
  14. https://www.unaids.org/en/resources/fact-sheet#:~:text=26%20million%20%5B25.1%20million%E2%80%9326.2,%20living%20with%20HIV%20in%202019
  15. Rehman GU and Shi H. “ABO and RH (D) blood groups distribution in Pakistan. a systematic review”. International Journal of Pure and Applied Zoology1 (2021): 1-9.
  16. https://www.who.int/news-room/fact-sheets/detail/malaria#:~:text%20=%20Malaria%20is%20caused%20by%20Plasmodium,%20vivax%20%E2%80%93%20pose%20the%20greatest%20threat
  17. https://www.who.int/docs/default-source/malaria/world-malaria-reports/9789240015791-double-page-view.pdf?sfvrsn%20=%202c24349d_5
  18. https://www.who.int/hac/crises/pak/Pakistan_Aug08.pdf
  19. Newman L., et al. “Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting”. PloS one12 (2015): e0143304.
  20. https://apps.who.int/iris/bitstream/handle/10665/246296/WHO-RHR-16.09-eng.pdf
  21. Rehman GU and Shi H. “ABO and RH (D) blood groups distribution in Pakistan. a systematic review”. International Journal of Pure and Applied Zoology1 (2021): 1-9.
  22. Anees M and Mirza MS. “Distribution of ABO and Rh blood group alleles in Gujrat region of Punjab, Pakistan”. Proceedings-Pakistan Academy of Sciences4 (2005): 233.
  23. Babar M., et al. “ABO and Rhesus blood group distribution in District Nowshera”. Journal of Postgraduate Medical Institute: Peshawar-Pakistan2 (1999).
  24. Anees M., et al. “Distribution of ABO and Rh blood group alleles in Mandi Bahauddin district of Punjab, Pakistan”. Proceedings-Pakistan Academy of Sciences4 (2007): 289-294.
  25. Alam S., et al. “ABO and Rh blood groups I. Markers of cardiovascular risk and association with lipids and other related risk covariables in a Pakistani population”. Proceedings-Pakistan Academy of Sciences1 (2005): 47-66.
  26. Hassan FM. “Frequency of ABO subgroup ABO and Rh (D) blood groups in major Sudanese ethnic groups”. Pakistan Journal of Medical Research1 (2010).
  27. Rehman GU and Shi H. “ABO and RH (D) blood groups distribution in Pakistan. a systematic review”. International Journal of Pure and Applied Zoology1 (2021): 1-9.
  28. Pennap G., et al. “Frequency distribution of hemoglobin variants, ABO and rhesus blood groups among students of African descent”. British Microbiology Research Journal 2 (2011): 33-40.
  29. Zuberi SJ. “Seroepidemiology of HBV/HCV in Pakistan”. International Hepatology Communications1 (1996): 19-26.
  30. Mehmood S., et al. “National prevalence rate of hepatitis B and C in Pakistan and its risk factors”. Journal of Public Health 28 (2019): 751-764.
  31. Zuberi SJ. “Seroepidemiology of HBV/HCV in Pakistan”. International Hepatology Communications1 (1996): 19-26.
  32. Attaullah S., et al. “Prevalence of HBV and HBV vaccination coverage in health care workers of tertiary hospitals of Peshawar, Pakistan”. Virology Journal1 (2011): 275.
  33. Ali M., et al. “Hepatitis B virus in Pakistan. a systematic review of prevalence, risk factors, awareness status and genotypes”. Virology Journal1 (2011): 1-9.
  34. Jahan S. “Epidemiology of needlestick injuries among health care workers in a secondary care hospital in Saudi Arabia”. Annals of Saudi Medicine3 (2005): 233-238.
  35. Mehmood S., et al. “National prevalence rate of hepatitis B and C in Pakistan and its risk factors”. Journal of Public Health 28 (2019): 751-764.
  36. Tyagi S and Tyagi A. “Possible correlation of transfusion transmitted diseases with Rh type and ABO blood group system”. Journal of Clinical and Diagnostic Research JCDR9 (2013): 1930-1931.
  37. Sharma P., et al. “Distribution of transfusion transmitted infections in ABO and Rh blood groups. a 5 year study”. Annals of International Medical and Dental Research 5 (2017): 16-18.
  38. Mehmood S., et al. “National prevalence rate of hepatitis B and C in Pakistan and its risk factors”. Journal of Public Health 28 (2019): 751-764.
  39. Memon FA., et al. “Seroprevalence of transfusion transmitted infections among different blood group donors at Blood Bank LUMHS, Hyderabad”. Pakistan Journal of Medical Sciences2 (2017): 443-446.
  40. Alabdulmonem W., et al. “Sero-prevalence ABO and Rh blood groups and their associated transfusion-transmissible infections among blood donors in the central region of Saudi Arabia”. Journal of Infection and Public Health2 (2020): 299-305.
  41. Nigam JS., et al. “The prevalence of transfusion transmitted infections in ABO blood groups and Rh type system”. Hematology Reports4 (2014): 5602.
  42. Ali M., et al. “Thirty years of HIV in Pakistan. a systematic review of prevalence and current scenario”. Future Virology10 (2017): 609-623.
  43. Zaheer HA., et al. “Prevalence and trends of hepatitis B, hepatitis C and human immunodeficiency viruses among blood donors in Islamabad, Pakistan 2005-2013”. Journal of Blood Disorders and Transfusion 5 (2014): 217.
  44. Mahmoud NS. “Blood Groups and Susceptibility to Hepatitis C Virus Infection Among β-Thalassemia Patients”. Diyala Journal of Medicine1 (2018): 20-28.
  45. Woo SM., et al. “Risk of pancreatic cancer in relation to ABO blood group and hepatitis C virus infection in Korea. a case-control study”. Journal of Korean Medical Science2 (2013): 247.
  46. Sharma P., et al. “Distribution of transfusion transmitted infections in ABO and Rh blood groups. a 5 year study”. Annals of International Medical and Dental Research 5 (2017): 16-18.
  47. Nigam JS., et al. “The prevalence of transfusion transmitted infections in ABO blood groups and Rh type system”. Hematology Reports4 (2014): 5602.
  48. Nigam JS., et al. “The prevalence of transfusion transmitted infections in ABO blood groups and Rh type system”. Hematology Reports4 (2014): 5602.
  49. Sharma P., et al. “Distribution of transfusion transmitted infections in ABO and Rh blood groups. a 5 year study”. Annals of International Medical and Dental Research 5 (2017): 16-18.
  50. Abegaz SB. “Human ABO Blood Groups and Their Associations with Different Diseases”. BioMed Research International (2021).
Citation: Hafsa Shah., et al. "Seroprevalence TTI’s (Transfusion Transmitted Infections) Hepatitis C, Hepatitis B and Human Immunodeficiency Virus, VDRL and Malaria in Blood Donors of Peshawar KPK, Pakistan”. EC Emergency Medicine and Critical Care 6.4 (2022): 09-16.

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