Review Article
Volume 5 Issue 12 - 2021
The Conjugation of Pathogenicity Factors and Metabolic Adaptation in Streptococcus Pyogenes
Almagambetov KH*
Astana Medical University, Nursultan, Kazakhstan
Received: November 01, 2021; Published: November 26, 2021




Abstract

Streptococcus pyogenes belongs to the long-known and most relevant conditional human pathogens. Due to the production of various pathogenicity factors, S. pyogenes is adapted to colonize mucosal and cutaneous surfaces and to evade immune defense. These are surface structural components (M-proteins, factors binding blood proteins, lipoteichoic acids) and secreted proteins (pathogenicity enzymes - serine and cysteine proteinases, including C5a-peptidase; glycolytic enzymes - glyceraldehyde-3-phosphate dehydrogenase and α-enolase; streptolysin O, etc.). The same pathogenicity factor is involved in different stages of the infectious process, from adhesion, biofilm formation and invasion, to inhibition of complement components, immunoglobulins, disruption of opsonization and phagocytosis. S. pyogenes is capable of persistence within phagocytes. Under conditions of deficiency of glucose, the main source of energy production, the pathogen is capable of synthesizing ATP by catabolizing arginine. The conjugation of metabolic changes and virulent activity is controlled by bipartite and individual gene transcription regulators. Strategies to develop combined, recombinant vaccines based on pyogenic Streptococcus proteins are promising. Significant immunogenicity along with M-proteins, C5a peptidase and CspA protease was revealed in the regulatory proteins Rgg and MutR.

Keywords: Pathogenicity Factors; Metabolic Adaptation; Regulatory Proteins

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Citation: Almagambetov KH. “The Conjugation of Pathogenicity Factors and Metabolic Adaptation in Streptococcus Pyogenes”. EC Emergency Medicine and Critical Care 5.12 (2021): 99-104.

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