Abstract
Background: Sickle cell disease is an inherited disorder with a relatively significant prevalence in the kingdom of Saudi Arabia. The management of the condition necessitates compliance to certain guidelines. Our study aims to assess the approach of emergency departments physicians in Saudi hospitals to the presentation of Vaso-occlusive crisis.
Methods: A cross-sectional descriptive study, in Saudi Arabia, through a period of three months, starting from 15th of December 2020 to 15th of March 2021. The data were obtained using a predesigned online questionnaire sheet. Approvals from Ethics and Scientific Committees (UB-RES-2020-0052) of Batterjee Medical College were obtained before the conduction of the study.
Results: Majority of the Emergency department physicians stated that they approached the management of sickle cell patients presenting with painful episodes initially by physical examination 51 (34.2%). Preferred first step for the majority 86 (57.7%) was the administration of intravenous fluids for the aim of maintaining good hydration. 61 (40.9%) stated that they preferred instant administration of analgesia. The most common analgesic administered was morphine 97 (65%).
Conclusion: In our study we found that opioids as morphine are prescribed at an increased rate. Despite the adverse effects being known, especially tolerance, prescription of morphine remains to dominate. We recommend further assessment of parameters to enhance pain assessment in terms of reliability.
Keywords: Anemia; Sickle Cell Disease; Saudi Arabia; Emergency Physician; Vaso-Occlusive Crisis
References
- Jastaniah W. “Epidemiology of sickle cell disease in Saudi Arabia”. Annals of Saudi Medicine3 (2011): 289-293.
- Al-Qureshi MM., et al. “The prevalence of sickle cell disease in Saudi children and adolescents. A community-based survey”. Saudi Medical Journal10 (2008): 1480-1483.
- El-Hazmi MA., et al. “Consanguinity among the Saudi Arabian population”. Journal of Medical Genetics8 (1995): 623-626.
- Borhade MB and Kondamudi NP. “Sickle Cell Crisis”. [Updated 2020 Nov 21]. Stat Pearls. Treasure Island (FL): StatPearls Publishing (2020).
- Tanabe P., et al. “Adult emergency department patients with sickle cell pain crisis: results from a quality improvement learning collaborative model to improve analgesic management”. Academic Emergency Medicine4 (2012): 430-438.
- Glassberg JA. “Improving emergency department-based care of sickle cell pain. Hematology 2014, the American Society of Hematology Education Program Book 1 (2017): 412-417.
- National Institutes of Health Heart, Lung, and Blood Diseases; The management of sickle cell disease.
- Yusuf HR., et al. “Emergency department visits made by patients with sickle cell disease: a descriptive study, 1999–2007”. American Journal of Preventive Medicine4 (2010): S536-541.
- Benjamin LJ., et al. “Quick reference guide for emergency department clinicians. American Pain Society; Glenview IL: 2001”. Guideline for the Management of Acute Pain in Sickle-Cell Disease (2001).
- Sickle Cell Society. Standards for the clinical care of adults with sickle cell disease in the United Kingdom”. Sickle Cell Society; London, UK (2008).
- Platt OS., et al. “Mortality in sickle cell disease--life expectancy and risk factors for early death”. New England Journal of Medicine23 (1994): 1639-1644.
- Shapiro BS., et al. “Sickle cell-related pain: perceptions of medical practitioners”. Journal of Pain and Symptom Management3 (1997): 168-174.
- Koshy M., et al. “Evaluation and Management of Sickle Cell Disease in the Emergency Department (An 18-year Experience): 1974—1992”. American Journal of Therapeutics4 (1994): 309-320.
- Glassberg JA., et al. “Emergency provider analgesic practices and attitudes toward patients with sickle cell disease”. Annals of Emergency Medicine4 (2013): 293-302.
- Zempsky WT. “Evaluation and treatment of sickle cell pain in the emergency department: paths to a better future”. Clinical Pediatric Emergency Medicine4 (2010): 265-273.
- Jovey RD. “Opioids, pain, and addiction–practical strategies”. British Journal of Pain1 (2012): 36-42.
- Savage SR., et al. “Challenges in using opioids to treat pain in persons with substance use disorders”. Addiction Science and Clinical Practice2 (2008): 4.
- Wu SM., et al. “The addiction behaviors checklist: validation of a new clinician-based measure of inappropriate opioid use in chronic pain”. Journal of Pain and Symptom Management4 (2006): 342-351.
- Saudi Ministry of Health Pocket Manual in Emergency Medicine; Sickle cell disease in emergency department.
- Saudi Ministry of Health; Health Awareness; Hematology, Sickle Cell Anemia.
Journal Menu
PubMed Indexed Article
EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.
PMID: 31143884 [PubMed]
PMCID: PMC6536005
EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.
PMID: 31565701 [PubMed]
PMCID: PMC6764777
EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.
PMID: 27747317 [PubMed]
PMCID: PMC5065347
EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?
PMID: 31460519 [PubMed]
PMCID: PMC6711478
EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?
PMID: 30215059 [PubMed]
PMCID: PMC6133253
EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.
PMID: 30417173 [PubMed]
PMCID: PMC6226033
EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.
PMID: 30264037 [PubMed]
PMCID: PMC6155992
EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.
PMID: 30198026 [PubMed]
PMCID: PMC6124505
EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.
PMID: 30294723 [PubMed]
PMCID: PMC6169793
EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs
PMID: 29285526 [PubMed]
PMCID: PMC5743211
EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique
PMID: 29911204 [PubMed]
PMCID: PMC5999047
EC Microbiology
Macrophages and the Viral Dissemination Super Highway
PMID: 26949751 [PubMed]
PMCID: PMC4774560
EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.
PMID: 27390782 [PubMed]
PMCID: PMC4933318
EC Microbiology
Reactive Oxygen Species in HIV Infection
PMID: 28580453 [PubMed]
PMCID: PMC5450819
EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population
PMID: 26280024 [PubMed]
PMCID: PMC4533840
EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis
PMID: 28066845 [PubMed]
PMCID: PMC5214344
EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology
PMID: 28936490 [PubMed]
PMCID: PMC5604476
EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia
PMID: 28713879 [PubMed]
PMCID: PMC5510658
EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature
PMID: 28133641 [PubMed]
PMCID: PMC5267489
EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling
PMID: 29333536 [PubMed]
PMCID: PMC5766278
EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.
PMID: 31032493 [PubMed]
PMCID: PMC6483108
EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.
PMID: 30957099 [PubMed]
PMCID: PMC6448571
EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.
PMID: 30101228 [PubMed]
PMCID: PMC6086333
EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.
PMID: 31080964 [PubMed]
PMCID: PMC6508883
EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.
PMID: 31093608 [PubMed]
PMCID: PMC6513001
EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.
PMID: 31552397 [PubMed]
PMCID: PMC6758937
EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.
PMID: 31681909 [PubMed]
PMCID: PMC6824723
EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.
PMID: 31681910 [PubMed]
PMCID: PMC6824726
EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.
PMID: 31528859 [PubMed]
PMCID: PMC6746603
EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?
PMID: 31276119 [PubMed]
PMCID: PMC6604646
EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.
PMID: 31406965 [PubMed]
PMCID: PMC6690616
EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.
PMID: 31517314 [PubMed]
PMCID: PMC6741290
EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.
PMID: 31633124 [PubMed]
PMCID: PMC6800226
EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.
PMID: 29662969 [PubMed]
PMCID: PMC5898812
EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.
PMID: 30215058 [PubMed]
PMCID: PMC6133268
News and Events
January Issue Release
We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.
Submission Deadline for Upcoming Issue
ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before February 10, 2023.
Certificate of Publication
ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.
Best Article of the Issue
Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.
Certifying for Review
ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.
Latest Articles
The latest articles will be updated immediately on the articles in press page of the respective journals.