Volume 5 Issue 8 - 2021
All about Helminths and Anthelmintics
Mohammad Salim*
Professor, Department of Botany, S. G. S. Govt. Autonomous P.G. College, Sidhi, Affiliated to A.P.S. University, Rewa, MP, India
*Corresponding Author: Mohammad Salim, Professor, Department of Botany, S. G. S. Govt. Autonomous P.G. College, Sidhi, Affiliated to A.P.S. University, Rewa, MP, India.
Received: July 18, 2021; Published: July 28, 2021

Helminths are a general term for parasitic worms. They are widely distributed in tropical and subtropical areas with more prevalently occurring in sub-Saharan Africa, America, China and east Asia. Humans harbour nearly 300 species of parasitic worms either derived from their primate ancestors or domestic animals. And, as the people infected with them are usually asymptotic, no one actually cares about it unless they are in large numbers. They are multicellular, eukaryotic, invertebrate animals generally requiring a living host to survive. Helminths are distinguished in having specific attachment organs like hooks and suckers, lips, teeth and dentary plates as their mouth parts. These are either nematodes (roundworms), cystodes (tapeworms) or trematodes (flatworms or flukes). Roundworms are usually found cylindrical in shape and appear round in cross section. Similarly, while tapeworms are always segmented flatworms, the trematodes are unsegmented flatworms or flukes. They are usually transmitted via contaminated soil water or food. Sometimes, these worms are entered in the body by actively penetrating the skin [1-3].


  1. Machicado C and Marcos LA. “Carcinogenesis associated with parasite other than Schistosoma, Opisthorchis and Clonorchis: A systematic Review”. International Journal of Cancer12 (2016): 2915-2921.
  2. Lalchhandama K. “The making of oncology: The tales of false carcinogenic worms”. Science Vision 11 (2017): 33-52.
  3. Monica CB Jaochim. “Editorial: Parasites and cancer”. Frontiers in Medicine (2019): 6.
  4. Wu ML and Jones VA. “Ascaris lumbricoides”. Achieves of pathology and Laboratory Medicine1 (2000): 174-175.
  5. Kemp C and Roberts A. “Infectious diseases: echinococcosis, hydatid disease”. Journal of the American Association of Nurse Practitioners8 (2001): 346-347.
  6. Wang KX., et al. “Fasciolopsiasis presenting as intestinal obstruction: a case report”. Chinese Journal of General Surgery 43 (2005): 1168.
  7. Tomas S., et al. “Update on the human broad tapeworm, Genus Diphyllobothrium including clinical relevance”. Clinical Microbiology Reviews 22.1 (2009): 146-160.
  8. White AC. “New development in the management of neurocysticerosis”. The Lancet Infectious Diseases9 (2009): 1261-1262.
  9. Rajendran S., et al. “Enterobius granulomas as a cause of abdominal pain”. BMJ Case Reports 18 (2015): 2015210464.
  10. Wei K., et al. “Hookworm infection: a neglected cause of overt obscure gastrointestinal bleeding”. The Korean Journal of Parasitology4 (2017): 391-398.
  11. Carpio A., et al. “Neurocysticercosis: the good, the bad and the missing”. Expert Review of Neurotherapeutics4 (2018): 289-301.
  12. Xia Y., et al. “Hemorrhagic stroke and cerebral paragonimiasis”. Stroke 45 (2014): 3420.
  13. Kim TS., et al. “Chlonorchis sinensis, an oriental liver fluke, as a human biological agents of cholangiocarcinoma: a brief review”. BMB Reports11 (2016): 590-597.
  14. Machicado C., et al. “Association of Fasciola hepatica infection with liver fibrosis, cirrhosis and cancer: A systematic review”. PLOS Neglected Tropical Diseases9 (2016): e0004962.
  15. Berry A., et al. “Urinary schistosomiasis and cancer”. Bulletin de la Societe de Pathologie Exotique1 (2017): 68-75.
  16. Hughes T., et al. “Opisthorchiasis and cholangiocarcinoma in Southeast Asia: an unresolved problem”. International Journal of General Medicine 10 (2017): 227-237.
  17. Martin RJ. “Modes of action of anthelmintic drugs”. The Veterinary Journal1 (1997): 11-34.
  18. Perez JL., et al. “Antiparasitic drugs. Review of the useful drugs in the treatment of classic and emergent parasitic diseases”. Revista Española de Quimioterapia2 (2009): 93-105.
  19. Piyush Y and Rupali S. “A review on anthelmintic drugs and their future scope”. International Journal of Pharmacy and Pharmaceutical Sciences3 (2011): 17-21.
  20. Luder PJ., et al. “Treatment of hydatid disease with high oral doses of mebendazole. Long term follow- up of plasma mebendazole levels and drug interactions”. European Journal of Clinical Pharmacology4 (1986): 443-448.
  21. Lacey E. “Mode of action of benzimidazoles”. Parasitology Today4 (1990): 112-115.
  22. Chen KT., et al. “Outbreak of Stevens- Johnson syndrome/ toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan”. American Journal of Public Health3 (2003): 489-492.
  23. Ahmad A., et al. “Albendazole in intestinal helminthiasis”. Journal of Pakistan Medical Association 36 (1986): 114-117.
  24. Horton J. “Albendazole: A review of anthelmintic efficacy and safety in humans”. Parasitology 121 (2000): 113-132.
  25. Ashour DS. “Invermectin from theory to clinical application”. International Journal of Antimicrobial Agents 2 (2019): 134-142.
  26. Martin RJ., et al. “Ivermectin: An anthelmintic, an insecticide and much more”. Trends in Parasitology 1 (2021): 48-64.
  27. Tchuente LA., et al. “Efficacy of praziquantel against Schistosoma haematobium infection in children”. The American Society of Tropical Medicine and Hygiene 6 (2004): 778-782.
  28. Angelucci F., et al. “The anti- schistosomal drug praziquantel is an adenosine antagonist”. Parasitology 9 (2007): 1215-1221.
  29. Shen C., et al. “Collection of Clonorchis sinensis adult worms from infected humans after praziquantel treatment”. The Korean Journal of Parasitology 2 (2007): 149-152.
  30. Matthaiou Dk., et al. “Albendazole versus praziquantel in the treatment of neurocysticercosis: A meta- analysis of comparative trials”. PLOS Neglected Tropical Diseases3 (2008): e194.
  31. Castello JD., et al. “Mechanism of the paralyzing action of piparazine on Ascaris muscle”. British Journal of Pharmacology196 (1963): 463-477.
  32. Shrestha B., et al. “Comparison of antiheminthic activity between bisaryl benzyl piperazine and benzimidazole linked piperazine derivatives”. International Journal of Pharmaceutical Sciences and Research4 (2016): 1547-1555.
  33. Aubry ML., et al. “Aspects of the pharmacology of a new anthelmintic pyrantel”. British Journal of Pharmacology 38 (1970): 332-344.
  34. Martin RJ., et al. “Drug resistance and neurotransmitter receptors of nematodes recent studies on the mode of action of levamisole”. The Korean Journal of Parasitology 131 (2005): 71-84.
  35. Chen W., et al. “Niclosamide: Beyond an antihelminthic drug”. Cell Signal 41 (2018): 89-96.
Citation: Mohammad Salim. “All about Helminths and Anthelmintics”. EC Emergency Medicine and Critical Care 5.8 (2021): 53-56.

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