Research Article
Volume 5 Issue 7 - 2021
Effect of Erythrocyte Transfusion on Hemodynamic and Oxygenation Parameters in ICU Patients
Ahlem Trifi*, Asma Mehdi, Yosr Touil, Foued Daly, Cyrine Abdennebi, Sami Abdellatif and Salah Ben Lakhal
Medical Intensive Care Unit, University Hospital Center La Rabta and Faculty of Medicine, University Tunis, El Manar, Tunis, Tunisia
*Corresponding Author: Ahlem Trifi, Medical Intensive Care Unit, University Hospital Center La Rabta and Faculty of Medicine, University Tunis, El Manar, Tunis, Tunisia.
Received: June 07, 2021; Published: June 30, 2021


Objective: To investigate the effects of erythrocyte transfusion (ET) on systemic hemodynamic and oxygenation variables in ICU patients with non-hemorrhagic anemia.

Methods: A cross-sectional study with a comparative approach on paired series (before versus after ET) conducted in the medical intensive care unit (ICU) of the Rabta University Hospital Center, Tunis-Tunisia during a period of 1 year (July 2019 - July 2020). Were included, patients receiving ET for non-hemorrhagic anemia. Hemodynamic and oxygenation parameters were obtained using cardiac Ultrasound-Doppler coupled with arterial and central venous gases. All parameters were taken just before ET and compared with those taken 2 hours after ET. Secondly, the analysis was adjusted according to the presence or not of septic shock.

Results: 50 ET were studied in 36 patients. The transfusion of 1 RBC induced: a significant increase in Hb (from 6,8 to 7,9 g/dl, p < 10-3), in CaO2 (from 9.2 to 10.5 ml/dl, p < 10-3) and in ScVO2 (from 73.5% to 78%, p = 0.002) with a significant decrease in CO (from 5.77 to 4.7 l/mn, p = 0.009). The increase in Hb and CaO2 did not increase O2 delivery (DO2: from 526 to 514 ml/mn, p = 0.68) that it was related to the decrease in CO. Also, lactates level not changed. In patients with septic shock, it was revealed a significant decrease in CO and DO2 without change in ScVO2.

Conclusion: Despite the raise in Hb and CaO2 after ET, DO2 did not increase due to the decrease in CO resulting from the blood hyper-viscosity. In patients with septic shock, DO2 even decreased.

Keywords: Red Blood Cells; Transfusion; Cardiac Output; Haematosis; Intensive Care


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Citation: Ahlem Trifi., et al.“Effect of Erythrocyte Transfusion on Hemodynamic and Oxygenation Parameters in ICU Patients”. EC Emergency Medicine and Critical Care 5.7 (2021): 106-117.

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