Review Article
Volume 5 Issue 4 - 2021
Nanotechnology against COVID-19
Mohsen Mhadhbi1* and Khalil Khamassi2
1Laboratory of Useful Materials, National Institute of Research and Physical-chemical Analysis, Technopole Sidi Thabet, Tunisia
2Field Crop Laboratory, National Agricultural Research Institute of Tunisia, University of Carthage, Street Hedi Karray, Menzah 1, Tunis, Tunisia
*Corresponding Author: Mohsen Mhadhbi, Laboratory of Useful Materials, National Institute of Research and Physical-chemical Analysis, Technopole, Sidi Thabet, Tunisia.
Received: February 14, 2021; Published: March 31, 2021




Abstract

The coronavirus disease (COVID-19) pandemic, caused by the virus SARS-CoV-2, is believed to be originally transmitted from animal to human, at Wuhan (China) in December 2019. Yet, this theory is still under debate. It was recognized as a pandemic on March 11, 2020 by World Health Organization. Since then, clinicians, materials scientists, biologists, and pharmacists are collaborating to develop protocols, drugs, and vaccines to combat COVID-19. Thus, this pandemic has changed the life of all people around the world. In this vein, several researches concerning the role of nanotechnology helping in the fight against coronavirus disease have been conducted. In this paper, we provide the current solutions provided by nanotechnology to face the COVID-19 pandemic.

Keywords: Nanotechnology; Nanomedicine; Vaccine; Nanoparticle

References

  1. “World Health Organization” (2020).
  2. “World Health Organization” (2020).
  3. Kim SC. “Patent number KR20200032050A” (2020).
  4. “Editorial on Nanotechnology Versus Coronavirus”. Nature Nanotechnology 15 (2020): 617.
  5. Eduardo RH., et al. “Nanotechnology Responses to COVID-19”. Advanced Healthcare Materials 9 (2020): 2000979.
  6. Rasha I., et al. “Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients”. Theranostics13 (2020): 5932-5942.
  7. Al-Wafi R., et al. “Mechanical, microstructural properties and cell adhesion of Sr/Se-hydroxyapatite/graphene/polycaprolactone nanofibers”. Journal of Thermoplastic Composite Materials (2020): 089270572091278.
  8. Ahmed MK., et al. “Au-doped carbonated hydroxyapatite sputtered on alumina scaffolds via pulsed laser deposition for biomedical applications”. Journal of Materials Research and Technology 9 (2020): 8854-8866.
  9. Ahmed MK., et al. “Complex relationship between alumina and selenium-doped carbonated hydroxyapatite as the ceramic additives to electrospun polycaprolactone scaffolds for tissue engineering applications”. Journal of Alloys and Compounds 801 (2019): 70-81.
  10. Ahmed MK., et al. “Tuning the mechanical, microstructural, and cell adhesion properties of electrospun ε-polycaprolactone microfibers by doping selenium-containing carbonated hydroxyapatite as a reinforcing agent with magnesium ions”. Journal of Materials Science 54 (2019): 14524-14544.
  11. Doremalen N., et al. “Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1”. The New England Journal of Medicine16 (2020): 1564-1567.
  12. Pati R., et al. “Review on Nanoparticle vaccines against infectious diseases”. Frontiers in Immunology 9 (2018): 1-16.
  13. Coutelle C and Williamson R. “Liposomes and viruses for gene therapy of cystic fibrosis”. Journal of Aerosol Medicine 1 (1996): 79-88.
  14. Zeng C., et al. “Leveraging mRNAs sequences to express SARS-CoV-2 antigens in vivo”. BioRxiv (2020): 1-16.
  15. Matthew DS., et al. “COVID-19 vaccine development and a potential nanomaterial path forward”. Nature Nanotechnology 15 (2020): 646-655.
  16. European Patent Office, “ESPACENET Patent Search”. (2020).
  17. Itani R., et al. “Review on Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients”. Theranostics13 (2020): 5932-5942.
  18. Chen L and Liang J. “An overview of functional nanoparticles as novel emerging antiviral therapeutic agents”. Materials Science and Engineering C 112 (2020): 110924.
  19. Singh L., et al. “The role of nanotechnology in the treatment of viral infections”. Therapeutic Advances in Infectious Disease 4 (2017) 105-131.
  20. Gallucci S and Matzinger P. “Danger Signals: SOS to the Immune System”. Current Opinion in Immunology 13 (2001): 114-119.
  21. Irvine DJ., et al. “Synthetic Nanoparticles for Vaccines and Immunotherapy”. Chemical Reviews 115 (2015): 11109-11146.
  22. Reed SG., et al. “New Horizons in Adjuvants for Vaccine Development”. Trends in Immunology 30 (2009): 23-32.
  23. Blander JM and Medzhitov R. “Regulation of Phagosome Maturation by Signals from Toll-Like Receptors”. Science 304 (2004): 1014-1018.
  24. Reddy ST., et al. “Exploiting Lymphatic Transport and Complement Activation in Nanoparticle Vaccines”. Nature Biotechnology 25 (2007): 1159-1164.
  25. Park JE., et al. “Metal Nanoparticles for Virus Detection”. Chem Nano Mat 2 (2016): 927-936.
  26. Mokhtarzadeh A., et al. “Nanomaterial-Based Biosensors for Detection of Pathogenic Virus”. Trends in Analytical Chemistry 97 (2017): 445-457.
  27. Draz MS and Shafiee H. “Applications of Gold Nanoparticles in Virus Detection”. Theranostics 8 (2018): 1985-2017.
  28. Dykman LA and Khlebtsov NG. “Gold Nanoparticles in Biology and Medicine: Recent Advances and Prospects”. Acta Naturae 3 (2011): 34-55.
  29. Khan MS., et al. “Gold Nanoparticles: A Paradigm Shift in Biomedical Applications”. Advances in Colloid and Interface Science 199-200 (2013): 44-58.
  30. Ghosh SK and Pal T. “Interparticle Coupling Effect on the Surface Plasmon Resonance of Gold Nanoparticles: From Theory to Applications”. Chemical Reviews 107 (2007): 4797-4862.
  31. Lee Y., et al. “Nanoplasmonic on-Chip PCR for Rapid Precision Molecular Diagnostics”. ACS Applied Materials and Interface 12 (2020): 12533-12540.
  32. Qiu G., et al. “Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection”. ACS Nano 14 (2020): 5268-5277.
  33. Ahmed SR., et al. “Self-Assembled Star-Shaped Chiroplasmonic Gold Nanoparticles for an Ultrasensitive Chiro-Immunosensor for Viruses”. RSC Advances 7 (2017): 40849-40857.
  34. Medhi R., et al. “Nanoparticle-Based Strategies to Combat COVID-19”. ACS Applied Nano Materials 3 (2020): 8557-8580.
  35. Lung P., et al. “Nanoparticle Formulated Vaccines: Opportunities and Challenges”. Nanoscale 12 (2020): 5746-5763.
  36. Coleman CM., et al. “MERS-CoV Spike Nanoparticles Protect Mice from MERS-CoV Infection”. Vaccine 35 (2017): 1586-1589.
  37. World Health Organization (WHO). “Draft Landscape of COVID-19 Candidate Vaccines” (2020).
  38. Pimentel TAPF., et al. “Peptide Nanoparticles as Novel Immunogens: Design and Analysis of a Prototypic Severe Acute Respiratory Syndrome Vaccine”. Chemical Biology and Drug Design 73 (2009): 53-61.
  39. Wang C., et al. “Novel Chimeric Virus-Like Particles Vaccine Displaying MERS-CoV Receptor-Binding Domain Induce Specific Humoral and Cellular Immune Response in Mice”. Antiviral Research 140 (2017): 55-61.
  40. Carter DC., et al. “A Unique Protein Self-Assembling Nanoparticle with Significant Advantages in Vaccine Development and Production”. Journal of Nanomaterials 2020 (2020): 4297937.
  41. Kam YW., et al. “Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FccRII-dependent entry into B cells in vitro”. Vaccine 25 (2007): 729-740.
  42. Corapi W.V., et al. “Monoclonal antibody analysis of neutralization and antibody-dependent enhancement of feline infectious peritonitis virus”. Journal of Virology 66 (1992): 6695-6705.
Citation: Mohsen Mhadhbi and Khalil Khamassi. “Nanotechnology against COVID-19”. EC Emergency Medicine and Critical Care 5.4 (2021): 98-106.

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