Research Article
Volume 5 Issue 4 - 2021
The Use of Azithromycin and Paracetamol Therapy is Most Important for Faster Recovery of Patients with Coronavirus Disease (COVID-19)
Milorad Paunović*
University of Belgrade, Clinical Center of Serbia, Belgrade, Serbia
*Corresponding Author: Milorad Paunović, University of Belgrade, Clinical Center of Serbia, Belgrade, Serbia.
Received: February 27, 2021; Published: March 26, 2021


In this research we analyzed the influence of using of azithromycin and paracetamol therapy for the recovery of patients with Coronavirus disease (COVID-19). 392 patients (male, 55.1%; mean, 64.2 years old) who had positive the chain reaction genetic test real-time with reverse transcriptase (rRT-PCR test) and who had at least three symptoms characteristic of patients with COVID-19 we were allocated in two groups. For eight days, investigated group of patients (patients who had pneumonia and at least two more symptoms characteristic of patients with COVID-19), 196 patients used azithromycin and paracetamol like a therapy for COVID-19. Control group of patients (patients who had fever like one of symptoms characteristic of patients with COVID-19 and at least two symptoms more), 196 patients took only paracetamol. After eight days of therapy, the rRT-PCR test was performed again on the ninth day for all patients from both of investigated groups. In our research exist statistically significant correlation between COVID-19 and using of azythromycin and paracetamol like a therapy for COVID-19 (x2 = 2.312; p > 0.05).

Keywords: Coronavirus; Pneumonia; The Chain Reaction Genetic Test Real-Time With Reverse Transcriptase (Rrt-PCR Test); Therapy With Azithromycin And Paracetamol


  1. Cui J., et al. “Origin and evolution of pathogenic coronaviruses”. Nature Reviews Microbiology 17 (2019): 181-192.
  2. Ji W., et al. “Cross-species transmission of the newly identified coronavirus 2019-nCoV”. Journal of Medical Virology 92 (2020): 433-440.
  3. Lam TT., et al. “Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins”. Nature (2020).
  4. Zhang T., et al. “Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak”. Current Biology (2020).
  5. Khan S., et al. “The emergence of a novel coronavirus (SARS-CoV-2), their biology and therapeutic options”. Journal of Clinical Microbiology (2020): pii: JCM.00187-20.
  6. Vankadari N and Wilce JA. “Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26”. Emerging Microbes and Infections 9 (2020): 601-604.
  7. Callaway E. “Coronavirus vaccines: five key questions as trials begin”. Nature 579 (2020): 481.
  8. World Health Organization. Report of the WHO-China Joint Mission on coronavirus disease 2019 (COVID-19). Geneva: World Health Organization (2020).
  9. Guan WJ., et al. “China Medical Treatment expert group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China”. The New England Journal of Medicine (2020).
  10. Chen N., et al. “Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study”. Lancet 395 (2020): 507-513.
  11. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 395 (2020): 497-506.
  12. Wang D., et al. “Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus infected pneumonia in Wuhan, China”. The Journal of the American Medical Association (2020).
  13. Sun P., et al. “Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis”. Journal of Medical Virology (2020).
  14. Rodriguez-Morales AJ., et al. “Clinical, laboratory and imaging features of COVID-19: a systematic review and metaanalysis”. Travel Medicine and Infectious Disease (2020): 101623.
  15. Li lQ., et al. “2019 novel coronavirus patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis”. Journal of Medical Virology (2020).
  16. Lu X., et al. “SARS-CoV-2 infection in children”. The New England Journal of Medicine (2020).
  17. Cai J., et al. “A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features”. Clinical Infectious Diseases (2020): pii:ciaa198.
  18. Chen ZM., et al. “Diagnosis and treatment recommendations for pediatric respiratory infectioncaused by the 2019 novel coronavirus”. World Journal of Pediatrics (2020).
  19. Lu R., et al. “Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding”. Lancet 395 (2020): 565-574.
  20. Yan R., et al. “Structural basis for the recognition of the SARS-CoV-2 by fulllength human ACE2”. Science 367 (2020): 1444-1448.
  21. Chen Y., et al. “Structure analysis ofthe receptor binding of 2019-nCoV”. Biochemical and Biophysical Research Communications (2020).
  22. Coutard B., et al. “The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade”. Antiviral Research 176 (2020): 104742.
  23. Andersen KG., et al. “The proximal origin of SARS-CoV-2”. Nature Medicine (2020).
  24. Zou X., et al. “Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection”. Frontiers in Medicine (2020).
  25. Chen N., et al. “Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavi-rus pneumonia in Wuhan, China: a descriptive study”. Lancet 395 (2020): 507-513.
  26. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 395 (2020): 497-506.
  27. Wang D., et al. “Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus - infected pneumonia in Wuhan, China”. The Journal of the American Medical Association (2020).
  28. Sun P., et al. “Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: a single arm meta-analysis”. Journal of Medical Virology (2020).
  29. Tang N., et al. “Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia”. Journal of Thrombosis and Haemostasis (2020).
  30. Cao B., et al. “A trial of lopinavirritonavir in adults hospitalized with severe Covid-19”. The New England Journal of Medicine (2020).
  31. Wu C., et al. “Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China”. JAMA Internal Medicine (2020).
  32. Xu L., et al. “Liver injury during highly pathogenic human coronavirus infections”. Liver International (2020).
  33. Jin M and Tong Q. “Rhabdomyolysis as potential late complication associated with COVID-19”. Emerging Infectious Diseases (2020): 26.
  34. Shi S., et al. “Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China”. JAMA Cardiology (2020).
  35. Zhang Y., et al. “Coagulopathy and antiphospholipid antibodies in patients with Covid-19”. The New England Journal of Medicine (2020).
  36. Recalcati S. “Cutaneous manifestations in COVID-19: a first perspective”. The Journal of the European Academy of Dermatology and Venereology (2020).
Citation: Milorad Paunović. “The Use of Azithromycin and Paracetamol Therapy is Most Important for Faster Recovery of Patients with Coronavirus Disease (COVID-19)”. EC Emergency Medicine and Critical Care 5.4 (2021): 90-95.

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