Research Article
Volume 5 Issue 4 - 2021
The Use of Azithromycin and Paracetamol Therapy is Most Important for Faster Recovery of Patients with Coronavirus Disease (COVID-19)
Milorad Paunović*
University of Belgrade, Clinical Center of Serbia, Belgrade, Serbia
*Corresponding Author: Milorad Paunović, University of Belgrade, Clinical Center of Serbia, Belgrade, Serbia.
Received: February 27, 2021; Published: March 26, 2021




Abstract

In this research we analyzed the influence of using of azithromycin and paracetamol therapy for the recovery of patients with Coronavirus disease (COVID-19). 392 patients (male, 55.1%; mean, 64.2 years old) who had positive the chain reaction genetic test real-time with reverse transcriptase (rRT-PCR test) and who had at least three symptoms characteristic of patients with COVID-19 we were allocated in two groups. For eight days, investigated group of patients (patients who had pneumonia and at least two more symptoms characteristic of patients with COVID-19), 196 patients used azithromycin and paracetamol like a therapy for COVID-19. Control group of patients (patients who had fever like one of symptoms characteristic of patients with COVID-19 and at least two symptoms more), 196 patients took only paracetamol. After eight days of therapy, the rRT-PCR test was performed again on the ninth day for all patients from both of investigated groups. In our research exist statistically significant correlation between COVID-19 and using of azythromycin and paracetamol like a therapy for COVID-19 (x2 = 2.312; p > 0.05).

Keywords: Coronavirus; Pneumonia; The Chain Reaction Genetic Test Real-Time With Reverse Transcriptase (Rrt-PCR Test); Therapy With Azithromycin And Paracetamol

References

  1. Cui J., et al. “Origin and evolution of pathogenic coronaviruses”. Nature Reviews Microbiology 17 (2019): 181-192.
  2. Ji W., et al. “Cross-species transmission of the newly identified coronavirus 2019-nCoV”. Journal of Medical Virology 92 (2020): 433-440.
  3. Lam TT., et al. “Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins”. Nature (2020).
  4. Zhang T., et al. “Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak”. Current Biology (2020).
  5. Khan S., et al. “The emergence of a novel coronavirus (SARS-CoV-2), their biology and therapeutic options”. Journal of Clinical Microbiology (2020): pii: JCM.00187-20.
  6. Vankadari N and Wilce JA. “Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26”. Emerging Microbes and Infections 9 (2020): 601-604.
  7. Callaway E. “Coronavirus vaccines: five key questions as trials begin”. Nature 579 (2020): 481.
  8. World Health Organization. Report of the WHO-China Joint Mission on coronavirus disease 2019 (COVID-19). Geneva: World Health Organization (2020).
  9. Guan WJ., et al. “China Medical Treatment expert group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China”. The New England Journal of Medicine (2020).
  10. Chen N., et al. “Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study”. Lancet 395 (2020): 507-513.
  11. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 395 (2020): 497-506.
  12. Wang D., et al. “Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus infected pneumonia in Wuhan, China”. The Journal of the American Medical Association (2020).
  13. Sun P., et al. “Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis”. Journal of Medical Virology (2020).
  14. Rodriguez-Morales AJ., et al. “Clinical, laboratory and imaging features of COVID-19: a systematic review and metaanalysis”. Travel Medicine and Infectious Disease (2020): 101623.
  15. Li lQ., et al. “2019 novel coronavirus patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis”. Journal of Medical Virology (2020).
  16. Lu X., et al. “SARS-CoV-2 infection in children”. The New England Journal of Medicine (2020).
  17. Cai J., et al. “A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features”. Clinical Infectious Diseases (2020): pii:ciaa198.
  18. Chen ZM., et al. “Diagnosis and treatment recommendations for pediatric respiratory infectioncaused by the 2019 novel coronavirus”. World Journal of Pediatrics (2020).
  19. Lu R., et al. “Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding”. Lancet 395 (2020): 565-574.
  20. Yan R., et al. “Structural basis for the recognition of the SARS-CoV-2 by fulllength human ACE2”. Science 367 (2020): 1444-1448.
  21. Chen Y., et al. “Structure analysis ofthe receptor binding of 2019-nCoV”. Biochemical and Biophysical Research Communications (2020).
  22. Coutard B., et al. “The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade”. Antiviral Research 176 (2020): 104742.
  23. Andersen KG., et al. “The proximal origin of SARS-CoV-2”. Nature Medicine (2020).
  24. Zou X., et al. “Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection”. Frontiers in Medicine (2020).
  25. Chen N., et al. “Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavi-rus pneumonia in Wuhan, China: a descriptive study”. Lancet 395 (2020): 507-513.
  26. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 395 (2020): 497-506.
  27. Wang D., et al. “Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus - infected pneumonia in Wuhan, China”. The Journal of the American Medical Association (2020).
  28. Sun P., et al. “Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: a single arm meta-analysis”. Journal of Medical Virology (2020).
  29. Tang N., et al. “Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia”. Journal of Thrombosis and Haemostasis (2020).
  30. Cao B., et al. “A trial of lopinavirritonavir in adults hospitalized with severe Covid-19”. The New England Journal of Medicine (2020).
  31. Wu C., et al. “Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China”. JAMA Internal Medicine (2020).
  32. Xu L., et al. “Liver injury during highly pathogenic human coronavirus infections”. Liver International (2020).
  33. Jin M and Tong Q. “Rhabdomyolysis as potential late complication associated with COVID-19”. Emerging Infectious Diseases (2020): 26.
  34. Shi S., et al. “Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China”. JAMA Cardiology (2020).
  35. Zhang Y., et al. “Coagulopathy and antiphospholipid antibodies in patients with Covid-19”. The New England Journal of Medicine (2020).
  36. Recalcati S. “Cutaneous manifestations in COVID-19: a first perspective”. The Journal of the European Academy of Dermatology and Venereology (2020).
Citation: Milorad Paunović. “The Use of Azithromycin and Paracetamol Therapy is Most Important for Faster Recovery of Patients with Coronavirus Disease (COVID-19)”. EC Emergency Medicine and Critical Care 5.4 (2021): 90-95.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


May Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the May issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before May 24, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk