Research Article
Volume 5 Issue 3 - 2020
Determination of Vitamin D Concentration in Thalassemia Patients in Tikrit City-Iraq
Abdulhadi Mohamed Jumaa1*, Muaamar A Abdulghani2, Husam Ekrayem Salman3 and Mossa M Marbut1
1Department of Physiology, College of Medicine, Tikrit University, Tikrit, Iraq
2Salah Al-Deen Health Governorate, Iraq
3Al-Esraa University College, Department of Dentistry, Iraq
*Corresponding Author: Abdulhadi Mohamed Jumaa, Department of Physiology, College of Medicine, Tikrit University, Tikrit, Iraq.
Received: December 24, 2020; Published: February 26, 2021


Introduction: The thalassemia’s considered as a group of inherited blood diseases that carry similar hemoglobin abnormality especially in the synthesis of hemoglobin caused by absolute or relative defect in major components of alpha (α) or beta (β) proteins of adult haemoglobin (HbA). It is mostly complicated by reduction in the hemoglobin formation with higher rate of red blood cells destruction. Previous study, found that, there was predictive increment in liver enzymes level and addition to increase in the measurements of serum ferritin, Total serum bilirubin and IL-10.

Aim of the Study: The aim of the study is to determine the concentration of vitamin D in male thalassemia patients in Tikrit city.

Patients and Methods: This study was conducted in Tikrit city the first of March 2019 till the end of June 2019, at the outpatient unit in especial private hospital at Tikrit city - Iraq. Seventy subjects were participated in present study. The subjects were divided into 2 groups.

  • Group 1 = Thalassemic male patients age less than 18 years (40 patients)
  • Group 2 = Normal healthy male subjects less than 18 years (30 participants).

Full history was taken from all participants and all of them undertake full physical examination. All blood samples had been collected at afternoon after overnight fasting. Serum vitamin D was measured by immune assay methods by Abbot equipment and by vidas equipment.

Results: The results showed that there was a highly significant elevation (p ≤ 0.01) in the concentration of serum ferritin in thalassemic male patients as compare to normal control male subjects. In the present study, there was significant (p ≤ 0.01) elevation in the serum activities of AST, ALT and ALP in male patients in comparison to control groups. Also, in the present study, there is significant reduction in the (P < 0.01) concentration of vitamin-D3 concentration in patients with thalassemia.

Keywords: Thalassemia; Ferritin; Vitamin D; Liver Enzymes


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Citation: Abdulhadi Mohamed Jumaa., et al. “Determination of Vitamin D Concentration in Thalassemia Patients in Tikrit City-Iraq”. EC Emergency Medicine and Critical Care 5.3 (2021): 27-32.

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