Research Article
Volume 5 Issue 3 - 2021
Antimicrobial Effects of Bryophyllum pinnatum and Garcinia kola Juice against Selected Uropathogens
Nweke Nicholas Simeon1*, Amala Smart Enoch1 and Aaron Umasoye Udogadi2
1Department of Medical Laboratory Science, Rivers State University, Nkpolu-Port Harcourt, Nigeria
2Department of Medical Microbiology and Parasitology, College of Health Sciences, University of Port Harcourt, Nigeria
*Corresponding Author: Nweke Nicholas Simeon, Department of Medical Laboratory Science, Rivers State University, Nkpolu-Port Harcourt, Nigeria.
Received: November 12, 2020; Published: February 27, 2021


This study was aimed at determining the antimicrobial activities of Garcinia kola and Bryophyllum pinnatum juices on some selected uropathogens. The antimicrobial activities of the individual juice were tested and the synergistic activities of the combined neat juices of Garcinia kola and Bryophyllum pinnatum. The dilutions of the juices at concentrations of 75%, 50%, 25% and 10% were tested to determine their antimicrobial activities on the selected organisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus and Candida albicans. Agar well diffusion method was used on Muller-Hinton agar to check the susceptibility pattern. The juice of Garcinia kola showed the large zone of inhibition on E. coli with zone diameter of 22 mm at 100% concentration (neat), Garcinia kola was moderately sensitive to K. pneumoniae, P. mirabilis and C. albicans at the concentrations of 100% (neat) and 75%. S. aureus was resistance to Garcinia kola juice at all concentrations. Bryophyllum pinnatum showed antimicrobial activity against E. coli, K. pneumoniae, P. mirabilis, S. aureus but Candida albicans was resistant to it. The combination of Bryophyllum pinnatum and Garcinia kola juices showed some remarkable synergistic activities compared to when the juices were used individually. Staphylococcus aureus which was resistant to Garcinia kola and Candida albicans that was resistant to Bryophyllum pinnatum juice became susceptible to their combined juices at the concentrations of 75% and 100%.

Keywords: Antimicrobial Activity; Garcinia kola; Bryophyllum pinnatum; Juice; Uropathogens


  1. Williams R. “Antimicrobial resistance a global threat”. Essential Drug Monitor 1 (2000): 28-29.
  2. Pretorius JC., et al. “Growth inhibition of plant pathogenic bacteria and fungi by extracts from selected South African plant species”. South African Journal of Botany 20 (2003): 188-192.
  3. Moreillion P., et al. “Staphylococcus aureus Including Staphylococcal Toxic shock. Principles and Practice of Infectious diseases. 6th edition”. Churchill Livingstone Pennsylvania (2005): 2333-2339.
  4. Odunayo RA., et al.In vitro antimicrobial activity of crude extracts from plants Bryophyllum pinnatum and Kalanchoe crenata”. African Journal of Traditional, Complementary and Alternative Medicines3 (2007): 338-344.
  5. Gill LS. “Ethnomedical uses of plants in Nigeria”. University of Benin Press, University (1992).
  6. Aibinu I., et al. “Emergence of Quinolone Resistance amongst Escherichia coli strains isolated from clinical infections in some Lagos State Hospitals in Nigeria”. Nigerian Journal of Health and Biomedical Science2 (2007): 73-78.
  7. Oliver AS. “Plant Taxonomy and Biosystematics”. 2nd University Press Cambridge (1989): 125-152.
  8. Okwu DE and Josiah C. “Evaluation of the Chemical Composition of Bryophyllum Pinnatum”. Journal of Science 6 (2006): 30-37.
  9. Iwu MM. “Handbook of African medicinal Plants”. Boca Raton: CRC Press Inc (1993): 223-224.
  10. Iwu MM. Bitter kola’s many health benefits (2014).
  11. Okigbo RN and Mmeka EC. “Antimicrobial effects of three tropical plant extracts on Staphylococcus aureus, Escherichia coli and Candida albicans”. African Journal of Traditional Complementary and Alternative Medicine5.3 (2008): 226-229.
  12. Indabawa II and Arzai AH. “Antibacterial activity of Garcinia kola and cola nitida seed extracts”. Bayero Journal of Pure and Applied Sciences1 (2011): 52-55.
  13. Ajayi TO., et al. “Antimicrobial Activity of Garcinia kola (Heckel) Seed Extracts and Isolated Constituents Against Caries-causing Microorganisms”. African journal of Biomedical Research, 17 (2014): 165-171.
  14. Akinnibosun FI and Itedjere E. “Evaluation of the antibacterial properties and synergistic effect of Garcinia kola Heckel seed extract and honey on some bacteria”. African Journal of Microbiology Research3 (2013): 174-180.
Citation: Nweke Nicholas Simeon., et al. “Antimicrobial Effects of Bryophyllum pinnatum and Garcinia kola Juice against Selected Uropathogens". EC Emergency Medicine and Critical Care 5.3 (2021): 01-06.

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