Review Article
Volume 4 Issue 9 - 2020
Do Mushrooms also Cause Cancer in Human?
Mohammad Shahid Masroor1*, Mohammad Salim2, Shagufta Parween3 and IP Prajapati2
1People’s College of Dental Sciences and Research Center, People’s Univ., Bhopal (M.P.), India
2Sanjay Gandhi Smriti Government Autonomous P.G. College, Sidhi, A.P.S. Univ., Rewa (M.P.), India
3All India Institute of Medical Sciences (AIIMS), Bhopal (M.P.) India
*Corresponding Author: Mohammad Shahid Masroor, People’s College of Dental Sciences and Research Center, People’s Univ., Bhopal (M.P.), India.
Received: November 14, 2020; Published: December 10, 2020




Abstract

Mushrooms are not usually known to cause cancer. But this is a poignant truth that some of these poisonous mushrooms containing mycotoxins develop various ailments, diseases and even cancer in human. Peoples are unknowingly consuming the poisonous mushrooms as they are unable to identify them. It appears that no such integrated study has done so far in the past to make the people aware that how some of these mushrooms are toxic in developing cancer in human. The present paper deals with the study of some of these poisonous mushrooms containing mycotoxins causing several ailments, diseases and cancer in human.

Keywords:Mushrooms; Mycotoxins; Diseases and Cancer

References

  1. Mas A. “Mushrooms”. Journal of Hepatology2 (2005): 166-169.
  2. Nagaoka MH., et al. “Measurement of a genotoxic hydrazine, agaritine and its derivative by HPLC with fluorescence derivatization in the Agaricus mushroom and its products”. Chemical and Pharmaceutical Bulletin6 (2006): 922-924.
  3. Saviuc P and Danel V. “New syndromes in mushroom poisoning”. Toxicological Reviews 3 (2006): 199-209.
  4. Emmeline L and Jean PV. “Warning on false or true morels and button mushrooms with potential toxicity linked to hydrazinic toxins: an update”. Toxins 8 (2020): 482-492.
  5. Toth B., et al. “Tumor induction with the N- acetyl derivative of 4- hydroxymethylphenylhydrazine, a metabolite of agaritine of Agaricus bisporus”. Cancer Research1 (1978): 177-180.
  6. Toth B., et al. “Gastric tumorigenesis by a single dose of 4- (hydroxymethyl) benzenediazonium ion of Agaricus bisporus”. British Journal of Cancer 3 (1982): 417-422.
  7. Hashida C., et al. “Quantities of agaritine in mushrooms (Agaricus bisporous) and the carcinogenicity of mushroom methanol extracts on the mouse bladder epithelium”. Nihon Koshu Eisei Zasshi6 (1990): 400-405.
  8. Kondo K., et al. “The metabolisms of agaritine, a mushroom hydrazine in mice”. Food and Chemical Toxicology3 (2008): 854-862.
  9. Pyysalo H. “Some new toxic compounds in false morels. Gyromitra esculanta”. Naturwissenshaften 8 (1975): 395.
  10. Braun R., et al. “Consideration on the carcinogenicity of the mushroom poison gyromitrin and its metabolites”. Journal of Applied Toxicology 5 (1981): 243-246.
  11. Karlson-Stiber C and Person H. “Cytotoxic fungi- an overview”. Toxicon4 (2003): 339-349.
  12. Dart RC. “Mushrooms”. Medical Toxicology, Philadelphia, P.A.: Williams and Wilkins (2004): 1719-1735.
  13. Piqueras J. “Hepatotoxic Mushroom poisoning: diagnosis and management”. Mycopathologia 2 (1989): 99-110.
  14. Andler J., et al. “Antibody-Drug conjugate payloads”. Methods in Molecular Biology 1045 (2013): 51-70.
  15. Hechler T and Andler J. “Amanitin based ADCs with an improved therapeutic index”. Poster #633, AACR Annual Meeting (2015).
  16. Park JS., et al. “Four cases of successful treatment after Podostroma cornu-damae intoxication”. Hong Kong Journal of Emergency Medicine 1 (2016): 55-59.
  17. Sanggil C., et al. “Identification of trichothecene- type mycotoxins in toxic mushroom Podostroma cornu- damae and biological specimens from a fatal case by LC- QTOF/MS”. Forensic Science International 291 (2018): 234-244.
  18. Lee SR., et al. “Macrocyclic trichothecene mycotoxins from a deadly poisonous mushroom, Podostroma cornu- damae”. Journal of Natural Products 1 (2019): 122-128.
  19. Schulzova V., et al. “Influence of storage and household processing on the Agaricus content of the cultivated Agarcius mushroom”. Food Additives and Contaminants 9 (2002): 853-862.
  20. Schulzova V., et al. “Agaritine content of 53 Agaricus species collected from nature”. Food Additives and Contaminants 1 (2009): 82-93.
  21. Walton K., et al. “Bioactivation of the mushroom hydrazine, agaritin, to intermediates that bind covalently to proteins and induce mutations in the Ames test”. Carcinogenesis8 (1997): 1603-1608.
  22. Shephard SE and Schlatter C. “Covalent binding of agaritine to DNA In vivo”. Food and Chemical Toxicology 36 (1998): 971-974.
  23. Roupas P., et al. “Mushrooms and agaritine: A mini review”. The Journal of Functional Foods 2 (2010): 91-98.
  24. Mostafa E. “Chemical profile, agaritine and selenium of Agaricus bisporous”. Brazilian Archives of Biology and Technology: An International Journal 6 (2012): 911-920.
  25. Gao WN., et al. “Agaritine and its derivatives are potential inhibitors against HIV proteases”. Medicinal Chemistry3 (2007): 221-226.
  26. Ying L., et al. “Immunomodulating activity of Agaricus brasiliensis KA21 in mice and human volunteers”. Evidence-Based Complementary and Alternative Medicine 2 (2008): 205-219.
  27. Coulet M and Guillot J. “Poisoning by Gyromitra: a possible mechanism”. Medical Hypothesis4 (1982): 325-334.
  28. Meierbratschi A., et al. “Methylation of DNA in the rat by the mushroom poison gyromitrin”. Journal of Agricultural and Food Chemistry 5 (1983): 1117-1120.
  29. Bergman K and Hellenas KE. “Methylation of rat and mouse DNA by the mushroom poison gyromitrin and its metabolite monomethylhdrazine”. Cancer Letters2 (1992): 165-170.
  30. Lampe KF. “Toxic fungi”. Annual Review of Pharmacology and Toxicology 19 (1979): 85-104.
  31. Kirklin JK., et al. “Treatment of hydrazine- induced coma with pyridoxine”. New England Journal of Medicine17 (1976): 938-939.
  32. Toth B and Erickson J. “Reversal of the toxicity of hydrazine an analogue by pyridoxine hydrochloride”. Toxicology1 (1977): 31-36.
  33. Michael AM., et al. “Gyromitra mushrooms”. Clinical Toxicology Review5 (2001): 1-2.
  34. Xia Y., et al. “Mushroom toxins: chemistry and toxicology”. Journal of Agricultural and Food Chemistry 67 (2019): 5053-5071.
  35. Horowitz Km., et al. “Gyromitra mushroom toxicity”. In: Stat pearls ( Internet) Treasure Island (FL), Stat Pearls Publishing (2020).
  36. Garcia J., et al. “Amanita phalloides poisoning. Mechanism of toxicity and treatment”. Food and Chemical Toxicology 86 (2015): 41-55.
  37. Zheleva A., et al. “Free redical reactions might contribute to severe alpha amanitin hepatotoxicity- a hypothesis”. Medical Hypotheses 2 (2007): 361-367.
  38. Hallen H., et al. “A gene family encoding the major toxins of lethal Amanita mushrooms”. Proceedings of the National Academy of Sciences 48 (2007): 19097-19101.
  39. Horgan PA., et al. “The insensitivity of mushroom nuclear RNA polymerase activity to inhibition by amatoxins”. Archives of Microbiology3 (1978): 317-319.
  40. Meinecke B and Meinecke - Tillmann S. “Effects of α-amanitin on nuclear maturation of porcine oocytes In vitro”. Journal of Reproduction and Fertility1 (1993): 195-201.
  41. Ahn JY., et al. “Two cases of mushroom poisoning by Podostroma cornu- damae”. Yonsei Medical Journal 1 (2013): 265-268.
  42. Yoko S., et al. “Toxic principles of a poisonous mushroom Podostroma cornu- damae”. Tetrahedron39 (2001): 8277-8281.
  43. Kim HN., et al. “Two cases of incidental Podostroma cornu-damae poisoning”. Clinical and Experimental Emergency Medicine 3 (2016): 186-189.
Citation: Mohammad Shahid Masroor., et al. “Do Mushrooms also Cause Cancer in Human?”. EC Emergency Medicine and Critical Care 5.1 (2021): 20-27.

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