Research Article
Volume 5 Issue 1 - 2021
Prevalence and Factors Associated with Tb/HIV Co-Infection among Severely Acute Malnourished Children Admitted in Mulago National Referral Hospital
Namale Vivian Ssonko1,2*, Mupere Ezekiel1 and Judy Orikiriiza1
1Makerere University College of Health Sciences, Kampala, Uganda
2Department of Neurology, Irving Medical Center, Columbia University, New York, USA
*Corresponding Author: Namale Vivian Ssonko, Makerere University College of Health Sciences, Kampala, Uganda and Department of Neurology, Irving Medical Center, Columbia University, New York, USA.
Received: October 05, 2020; Published: December 10, 2020




Abstract

Objectives:: To determine the prevalence of Tuberculosis (TB)/Human Immunodeficiency virus (HIV) co-infection among severely malnourished children admitted in Mulago National Referral Hospital and determine the factors associated with co-infection in these children.

Methods:: This was a cross sectional study design which consecutively enrolled children aged 1 - 5 years who were severely malnourished, consented to the study and were admitted during the study period. We excluded children with severe co-morbidities which would otherwise increase risk of TB. A standardized questionnaire, HIV serology, MTB RIF gene x-pert on gastric aspirates, a tuberculin skin test (TST), MUAC, weight for Height Z scores and chest x-ray were performed on all children. HIV positive children who fulfilled criteria for TB diagnosis clinically or microbiologically were considered to have TB/HIV co-infection.

Results: A prevalence of TB/HIV co-infection of 20.2% (35/173) was found. Associated factors included positive contact of PTB AOR 10.7, (95% CI: 3.9 - 34.9), missed Bacilli Calmette-Guerin (BCG) vaccine AOR 1.2, (95% CI: 0.72 - 0.6), hypothermia AOR 10.7, (95% CI: 1.5 - 51.6), lymphadenopathy AOR 11.3, (95% CI: 2.1 - 39) and hepatomegaly AOR 6.2 (95% CI: 1.5 - 14.5).

Conclusion: While there was a high prevalence of TB/HIV co-infection, missed opportunity for early ART and IPT initiation was very high. Strengthening of implementation of guidelines on screening and initiation of TB, HIV treatment should be emphasized. High index of suspicion for all malnourished children presenting with hypothermia, lymphadenopathy and hepatomegaly.

Keywords: TB/HIV co-infection; SAM-NE; SAM-E; PTB; HIV

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Citation: Namale Vivian Ssonko., et al. “Prevalence and Factors Associated with Tb/HIV Co-Infection among Severely Acute Malnourished Children Admitted in Mulago National Referral Hospital”. EC Emergency Medicine and Critical Care 5.1 (2021): 01-13.

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