Research Article
Volume 4 Issue 12 - 2020
Protein C Level and Activated Partial Thromboplastin Time in Neonatal Sepsis
Albara Ahmed1, Babiker Mohammed2, Abdelhalim Nasr3, Wafa Elhag4, Awadelkareem Abass5 and Mosab Nouraldein Mohammed Hamad6*
1Assistant Professor, Department of Haematology, Alfajr College for Sciences Technology, Medical Laboratory Science Program, Khartoum, Sudan
2Professor of Pathology, Department of Pathology, Faculty of Medicine, Karari University, Omdurman, Sudan
3Associate Professor, Department of Microbiology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan
4Associate Professor of Neonatology, Department of Pediatrics, Faculty of Medicine, University of Bahri, Sudan
5Assistant Professor, Department of Haematology, Faculty of Medical Laboratory Science, University of Khartoum, Khartoum, Sudan
6Lecturer of Medical Parasitology, Department of Medical Laboratory Science, Phylum of Parasitology and Medical Entomology, Alfajr College for Sciences Technology, Khartoum, Sudan
*Corresponding Author: Mosab Nouraldein Mohammed Hamad, Lecturer of Medical Parasitology, Department of Medical Laboratory Science, Phylum of Parasitology and Medical Entomology, Alfajr College for Sciences Technology, Khartoum, Sudan.
Received: September 25, 2020; Published: November 07, 2020




Abstract

Aim: The researchers intended to evaluate Activated Partial Thromboplastin Time (APTT) and Protein C (PC) amongst Sudanese neonates with sepsis (Cases) in Omdurman maternity hospital, Sudan related with healthy neonates (controls) for recognizing haemostatic alteration in APTT and PC amongst neonatal sepsis which cumulative yearly in Sub Saharan African countries along with incessant home-grown efforts by governmental bodies and NGOs.

Results: An overall of 100 neonates alienated similarly into septic cases and healthy controls, died neonates were constituted 10 (20%) while 40 (80%) were recovered between case group.

APTT showed noteworthy continuation in septic neonates compared to controls (mean; 47.8 and 37.5 sec for cases and controls, respectively) P-value was 0.00. Amongst patients group: dead neonates exhibited significant prolongation matched recovered (mean; 61.5 and 44.4 sec) P-value 0.00. PC showed noteworthy reduction in dead neonates compared to recovered (mean; 25.4 and 36.2% for dead and improved). P-value 0.04.

Insignificant change in PC was found amid case and control group. None of the sex, gestational age, delivery method, sepsis onset, and causative agent displayed noteworthy correlation with APTT and PC. APTT&PC can be valuable as indicator of neonatal sepsis mortality.

Conclusion: APTT was meaningfully prolonged in neonatal sepsis (P-value 0.00). APTT also prolonged considerably in deceased septic neonates matched to recovered one (P-value 0.00). PC reduced expressively in dead neonates compared to recover in case group (P-value 0.04). Prolonged APTT and reduce PC can be valuable as a marker for neonatal sepsis mortality.

Keywords: Neonatal Sepsis; Mortality; APTT; PC; Sudan

References

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Citation: Mosab Nouraldein Mohammed Hamad., et al. “Protein C Level and Activated Partial Thromboplastin Time in Neonatal Sepsis”. EC Emergency Medicine and Critical Care 4.12 (2020): 07-11.

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