Research Article
Volume 4 Issue 10 - 2020
ACE Dwindle and Bradykinin Amelioration: The Avant-Garde Miscreant in the Pathophysiology of COVID-19
Rahul Sethi1*, Hasmik Zakharyan2 and Satenik Baghdasaryan3
1Head, Department of International Students’ Affairs, Clinical Resident, Department of Internal Diseases, Yerevan State Medical University, Consultant Physician to Embassy of India, Yerevan, Armenia
2Associate Professor, Department of Internal Diseases, Yerevan State Medical University, Yerevan, Armenia
3Associate Professor, Department of Endocrinology, Head, Center for Specialization and Continuing Education Yerevan State Medical University, Yerevan, Armenia
*Corresponding Author: Rahul Sethi, Head, Department of International Students’ Affairs, Clinical Resident, Department of Internal Diseases, Yerevan State Medical University, Consultant Physician to Embassy of India, Yerevan, Armenia.
Received: September 11, 2020; Published: September 24, 2020




Abstract

Background: COVID-19 has been talk of the town for medical fraternity at present as to date we are unable to find the exact treatment of the disease as the pathophysiology of the ailment is still not reveled completely. The new researches are pointing towards bradykinin which is a short chain of amino acids made up of kinin group of proteins that causes inflammation as main culprit of the disease. As the coagulation part of the COVID-19 is unknown and it is resistant to classical treatment of coagulopathies. In this article, we have postulated the bradykinin behind the coagulopathies through few basic blood analysis, different theoretical concepts and hypotheses affirming the certitude.

Materials and Methods: We studied bradykinin linked with COVID-19 and it’s general, physiological and pathological functions in subjects by checking their Angiotensin converting enzyme (ACE) levels in blood and has compared related studies on PubMed, Google Scholar and CDCs, showing linkage of coagulation in COVID-19 patients with bradykinin’s major role behind it.

Results: ACE levels were low in group of patients who were COVID-19 positive and have developed coagulopathies as a complication of the disease which gives an indirect idea of high levels of bradykinin in SARS-COV-2 infected patients, hence proving the idea behind the indignation.

Conclusion: The patients with coagulopathies happens to have a bradykinin storm and treating high levels of bradykinin might be an effective way of treating coagulopathies rather than treating it with conventional methods.

Keywords: Bradykinin; Bradykinin Storm; COVID-19; Angiotensin Converting Enzyme (ACE); Kinin-Kallikrein System; RAAS; Coagulopathies; Factor XII 

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Citation: Rahul Sethi., et al. “ACE Dwindle and Bradykinin Amelioration: The Avant-Garde Miscreant in the Pathophysiology of COVID-19”. EC Emergency Medicine and Critical Care 4.10 (2020): 54-59.

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