Research Article
Volume 4 Issue 10 - 2020
Can Exosome based Therapy Reduces the Severity of COVID-19?
Swatilekha Das*
School of Biotechnology, KIIT University, Bhubaneswar, India
*Corresponding Author: Swatilekha Das, School of Biotechnology, KIIT University, Bhubaneswar, India.
Received: August 31, 2020; Published: September 19, 2020




Abstract

In the last twenty years, several viral epidemics such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) has been recorded [1]. In recent times unexplained cases with low respiratory infections detected in Wuhan, China, and poses a big challenge for the whole world [1]. WHO (World Health Organization) formally named this disease as COVID-19 (Corona Virus disease 2019), which is later named by the International Committee on the taxonomy of virus as SARS-CoV-2. Wuhan isolated SARS-CoV-2 belongs to the Sarbecovirus subgenus and Betacoronavirus genus [2]. This virus has been spreading around the world widely. This raises an urgent need for an effective therapeutic approach. Recently different medicines and a combination of drugs have shown promising results. Many companies and researchers are working on finding a suitable vaccine or proper medication for COVID-19. In this review, we aim to provide basic structural information about COVID-19 and possible target to check the growth of these viruses by using exosome-based CRISPR/cas13d technology. Exosome incorporated CRISPR/Cas13d based system may specifically target viral ORF1ab and S RNA of COVID19 to knock down the ability to reproduce. This promising method needs proper investigation and if proven effective that will be an excellent development to fight against the COVID19 pandemic.

Keywords: Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV); Middle East Respiratory Syndrome Coronavirus (MERS-CoV); COVID-19 (Corona Virus Disease 2019)

References

  1. Sun P., et al. “Understanding of COVID-19 based on current evidence”. Journal of Medical Virology 6 (2020): 548-551.
  2. Robson B. “COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles’ heel conserved region to minimize probability of escape mutations and drug resistance”. Computers in Biology and Medicine 121 (2020): 103749.
  3. Alanagreh L., et al. “The human coronavirus disease covid-19: Its origin, characteristics, and insights into potential drugs and its mechanisms”. Pathogens5 (2020).
  4. Zhong LLD., et al. “Potential Targets for Treatment of Coronavirus Disease 2019 (COVID-19): A Review of Qing-Fei-Pai-Du-Tang and Its Major Herbs”. The American Journal of Chinese Medicine 5 (2020): 1051-1071.
  5. Li G and De Clercq E. “Therapeutic options for the 2019 novel coronavirus (2019-nCoV)”. Nature Reviews Drug Discovery 3 (2020): 149-150.
  6. Kushawah G., et al. “CRISPR-Cas13d induces efficient mRNA knock-down in animal embryos”. Bio Rxiv (2020).
  7. Nguyen TM., et al. “Virus against virus: a potential treatment for 2019-nCov (SARS-CoV-2) and other RNA viruses”. Cell Research 3 (2020): 189-190.
  8. Ohno SI., et al. “Systemically injected exosomes targeted to EGFR deliver antitumor microrna to breast cancer cells”. Molecular Therapy 1 (2013):185-191.
  9. Yuen KS., et al. “SARS-CoV-2 and COVID-19: The most important research questions”. Cell and Bioscience 1 (2020): 1-5.
  10. Yuki K., et al. “COVID-19 pathophysiology: A review”. Journal of Clinical Immunology (2020): 215.
  11. Johnson K and Kaitlin Johnson. “Activation Of A Transcription Dependent Crispr/Cas System (2019).
  12. Abbott TR., et al. “Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza”. Cell4 (2020): 865-876.
  13. Schindele A., et al. “CRISPR/Cas brings plant biology and breeding into the fast lane”. Current Opinion in Biotechnology 61 (2020): 7-14.
  14. Kalluri R and LeBleu VS. “The biology, function, and biomedical applications of exosomes”. Science 367.6478 (2020).
  15. Zhang X., et al. “Exosomes in cancer: Small particle, big player”. Journal of Hematology and Oncology 1 (2015): 1-13.
  16. Rilla K., et al. “Hyaluronan-Coated Extracellular Vesicles- A Novel Link between Hyaluronan and Cancer”. 1st edition. Elsevier Inc 123 (2014).
  17. O’Loughlin A., et al. “Exosomes and the Emerging Field of Exosome-Based Gene Therapy”. Current Gene Therapy 4 (2012): 262-274.
  18. Cooper LF., et al. “A Role for Exosomes in Craniofacial Tissue Engineering and Regeneration”. Frontiers in Physiology (2020).
Citation: Swatilekha Das. “Can Exosome based Therapy Reduces the Severity of COVID-19?”. EC Dental Science 19.10 (2020): 44-50.

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