Review Article
Volume 4 Issue 10 - 2020
Human Papillomaviruses Capable of Causing Cancer in Human
Mohammad Shahid Masroor1, Mohammad Salim2*, Shagufta Parween3 and Hidayat-Ulla Khan4
1People’s College of Dental Sciences and Research Center, People’s University, Bhopal, MP, India
2Sanjay Gandhi Smriti Government Autonomous P.G. College, Sidhi, APS University, Rewa, MP, India
3All India Institute of Medical Sciences (AIIMS), Bhopal, MP, India
4Government Model Science College, Rewa, APS University, Rewa, MP, India
*Corresponding Author: Mohammad Salim, Sanjay Gandhi Smriti Government Autonomous P.G. College, Sidhi, APS University, Rewa, MP, India.
Received: August 27, 2020; Published: August 19, 2020


The extremely common worldwide human papillomaviruses have been known to the society since the time of Hippocrates in 300 BC mostly causing genital infections in human. This is observed that human papillomaviruses are extremely contagious viruses affecting only humans. Once infected, a person cannot get rid of them. Most of the individuals are infected even only after the onset of courtship without being engaged in sexual intercourse. These infections are usually asymptomatic resolving spontaneously in due course of time, but if persisted for long, it with pink in colour develops genital warts or precancerous lesions in future. The HPVs developing genital warts are different from that of causing cancers. Only a small number of strains can cause genital warts. The authors opined that the hidden asymptomatic carriers are the most typical risk group of individuals in transmission of these viruses. The aim of this paper is not only to make the people aware of the fact that human papillomaviruses are unknowingly being transmitted in the society via skin to skin contact during oral, genital or anal sex but these viruses if persisted for a longer period of time in the human body may develop cancer in future. The Present paper deals with the study of human papillomaviruses causing cancer in human in the light of recent researches done so far in the field of viral origin of cancer.

Keywords: Human Papillomaviruses; Genital Warts; Cancer


  1. Zur Hausen H. “Human papillomaviruses in the pathogenesis of anogenital cancer”. Virology 184 (1991): 9-13.
  2. Grulich A., et al. “Cancers attributable to human papillomavirus infection”. Sexual Healing 7 (2010): 244-252.
  3. Zayko MO., et al. “Condyloma acuminata presenting as isolated papillary lesions in the prostatic urethra”. American Journal of Case Reports 19 (2018): 1522-1525.
  4. Leslie SW., et al. “Gential warts In: Stat Pearls”. Treasure Island (FL): Stat Pearls Publishing (2019).
  5. Parkin DM. “The global health burden of infections associated cancers in the year 2002”. International Journal of Cancer 118 (2006): 3030-3044.
  6. Steinbrook R. “The potential of human papillomavirus vaccines”. New England Journal of Medicine 354 (2006): 1109-1112.
  7. Pahud BA and Ault KA. “The expanded impact of human papillomavirus vaccine”. Infectious Disease Clinics of North America (Review) 29 (2015): 715-724.
  8. Palefsky JM., et al. “Prevalence and risk factors for human papillomaviurs infection of the anal canal in human immunodeficiency virus (HIV)- positive and HIV-negative homosexual men”. The Journal of infectious Diseases 177 (1998): 361-367.
  9. Stratton KL and Culkin DJ. “A contemporary review of HPV and penile cancer”. Oncology 30 (2016): 245-249.
  10. Young D., et al. “Increase in head and neck cancer in younger patients due to HPV”. Oral Oncology 51 (2016): 727-730.
  11. Ozaydin-Yavuz G., et al. “Determinants of high risk human papillomavirus infection in anogenital warts”. General Advances in Dermatology and Allergology/Postępy 36 (2019): 76-81.
  12. Niloofar K., et al. “Human papillomavirus and breast cancer: the role of inflammation and viral expressed proteins”. BMC Cancer 19 (2019): 1-11.
  13. Moustafa AA., et al. “Human papillomaviruses related cancers”. Human Vaccines and Immunotherapeutics 10 (2014): 1812-1821.
  14. Nadia AS., et al. “Association of high risk human papillomavirus and breast cancer: A UK based study”. Scientific Reports 7 (2017): 43591-43598.
  15. Sher G., et al. “Prevalence and type distribution of high- risk human papillomavirus (HPV) in breast cancer: A Qatar based study”. Cancers (Basel) 12 (2020): 1528-1536.
  16. Islam MS., et al. “Human papillomavirus (HPV) profiles in breast cancer: future management”. Annals of Translational Medicine 8 (2020): 650-662.
  17. Lawson JS and Wendy KG. “Evidence for a causal role by human papillomaviruses in prostate cancer – a systematic review”. Infectious Agents and Cancer 15 (2020): 1-11.
  18. Argyri E., et al. “Investigating the role of human papillomavirus in lung cancer”. Papillomavirus Research 3 (2017): 7-10.
  19. Larisse SDL. “Detection of human papillomavirus and the role of p16INK4a in colorectal carcinoma”. PLoS One6 (2020): e0235065.
  20. Michele V., et al. “Evidence of association of Human papillomavirus worsening in glioblastoma multiforme”. Neuro- Oncology 16 (2014): 298-302.
  21. Scheffner M., et al. “The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53”. Cell 63 (1990): 1129-1136.
  22. Eun-Kyoung Yim and Jong-Sup park. “The role of HPV E6 and E7 oncoproteins in HPV-associated cervical carcinogenesis”. Cancer Research and Treatment 37 (2005): 319-324.
  23. Jiezhong Chen and Kong-Nan Zhao. “HPV-p53-mi R-34a axis in HPV-associated cancers”. The Annals of Translational Medicine 21 (2015): 331-337.
  24. Wang Ya-Wen., et al. “HPV status and its correlation with BCL2, p21, p53, Rb and surviving expression in breast cancer in a chinese population”. BioMed Research International (2017).
  25. Mustaq M., et al. “DNA tumor viruses and cell metabolism”. Oxidative Medicine and Cellular Longevity (2016): 6468342.
  26. Guan P., et al. “Human papillomaviruses types in 1,15,789 HPV-positive women : A meta-analysis from cervical infection to cancer”. International Journal of Cancer 131 (2012): 2349-2359.
  27. Nowinska K., et al. “The role of human papillomavirus in oncogenic transformation and its contribution to the etiology of precancerous lesions and cancer of the larynx: A review”. Advances in Clinical and Experimental Medicine 26 (2017): 539-547.
  28. Tarik Gheit. “Mucosal and cutaneous human papillomavirus infections and cancer biology”. Frontiers in Oncology (2019).
  29. Gogilashvili K., et al. “The role of human papillomavirus in oral squamous cell carcinoma (review)”. Georgian Medical News 213 (2012): 32-36.
  30. Syrjanen S. “Oral manifestations of human papillomavirus infections”. The European Journal of Oral Sciences 126 (2018): 49-66.
  31. Zur Hausen H. “Papillomaviruses and cancer: from basic studies to clinical applications”. Nature Reviews Cancer 2 (2002): 342-350.
  32. Tolstov Y., et al. “Human papillomaviruses in urologic malignancies : a critical assessment”. Urologic Oncology 32 (2014): 19-27.
  33. Do HT., et al. “The etiologic role of human papillomavirus in penile cancers : a study in Vietnam”. British Journal of Cancer 108 (2013): 229-233.
  34. Leung AK., et al. “Penile warts : an update on their evaluation and management”. Drugs Context (2018).
  35. Lisboa C., et al. “High prevalence of human papillomavirus on anal and oral samples from men and women with external anogenital warts: The HERCOLES Study”. Acta Dermato-Venereologica 99 (2019): 557-563.
  36. Lei J., et al. “High risk human papillomavirus status and prognosis in invasive cervical cancer: A nationwide cohort study”. PLOS Medicine 15 (2018): e1002666.
  37. Zur Hausen H. “Autobiography”. org (2010).
  38. De sanjose., et al. “Human papillomavirus genotype attribution in invasive cervical cancer. A retrospective cross sectional worldwide study”. The Lancet Oncology 11 (2010): 1048-1056.
  39. Rosa AD., et al. “Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence and apoptosis in HeLa cervical carcinoma cells”. Journal of Virology 77 (2003): 1551-1563.
  40. Yim EK and Park JS. “The role of HPV E6, and E7 oncoproteins in HPV associated cervical carcinogeniss”. Cancer Research Treatment 37 (2005): 319-324.
  41. Asmita P and Rita K. “Human papillomavirus E6 and E7: The cervical cancer hallmarks and targets for therapy frontiers in Microbiology (2020).
  42. Masroor MS., et al.Salmonella typhi causing gallbladder cancer in human”. National Journal of Life Sciences 15 (2018): 143-144.
  43. Masroor MS., et al. “Recent trends in the study of Helicobacter pylori developing stomach cancer in human”. International Journal of Medical and Health Research 5 (2019): 76-80.
Citation: Mohammad Salim., et al. “Human Papillomaviruses Capable of Causing Cancer in Human”. EC Emergency Medicine and Critical Care 4.10 (2020): 38-43.

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