Mini Review
Volume 4 Issue 9 - 2020
Unusual Enzymes in Corona Virus Genome and their Roles in Pathogenicity Control and Drug Design
Asit Kumar Chakraborty*
Associate Professor of Biochemistry, Genetic Engineering Laboratory, Oriental Institute of Science and Technology, West Bengal, Vidyasagar University, Midnapore, India
*Corresponding Author: Asit Kumar Chakraborty, Associate Professor of Biochemistry, Genetic Engineering Laboratory, Oriental Institute of Science and Technology, West Bengal, Vidyasagar University, Midnapore, India.
Received: July 08, 2020; Published: August 08, 2020




Abstract

Corona virus pandemic has threatened entire human population of this earth and within few months > 10 millions infections and > 600000 deaths and human activities have totally suffered due to lock down. Corona virus RNA-dependent RNA polymerase (nsp12), proteases (Nsp3 and nsp5) have been targeted for drug design as well as spike protein (S) and nucleocapsid protein (N). I predicted non-structural polyprotein-derived RNA topoisomerase (nsp2) and six rRNA methyltransferases (nsp8, nsp9, nsp10, nsp13, nsp14 and nsp16) as therapeutic targets. Previously nsp13 was published as RNA helicase, nsp16 as 2’-0-cappying methyltransferase and nsp14/nsp15 as ribonucleases. We found all Corona virus enzymes have weak similarities to different Escherichia coli ribosomal proteins and might be inhibitory to host ribosome turnover, protein synthesis and oxidative phosphorylation. Nsp2 RNA topoisomerase might be important for drug design and vaccine development. However, antisense, ribozyme and nanotech drug designs could be beneficiary to those patients having very high virus load.

Keywords: Corona Virus; Pathogenicity Control; Drug Design

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Citation: Asit Kumar Chakraborty. “Unusual Enzymes in Corona Virus Genome and their Roles in Pathogenicity Control and Drug Design”. EC Emergency Medicine and Critical Care 4.9 (2020): 45-50.

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