Research Article
Volume 4 Issue 8 - 2020
Studies on Mean White Blood Counts in Malaria Infected Mice Treated with Antioxidants
Esimai Bessie Nonyelum1*, Obeagu Emmanuel Ifeanyi2 and Eneanaya CI3
1Department of Medical Laboratory Science, Evangel University Akaeze, Ebonyi State, Nigeria
2Department of Medical Laboratory Science, Imo State University, Owerri, Nigeria
3Department of Parasitology and Entomology Faculty of Applied Natural Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
*Corresponding Author: Esimai Bessie Nonyelum, Department of Medical Laboratory Science, Evangel University Akaeze, Ebonyi State, Nigeria.
Received: June 20, 2020; Published: July 15, 2020




Abstract

A parasitologic evaluation of blood samples of 2000 symptomatic malaria patients (1000 males and 1000 females) in some health facilities of Enugu metropolis was conducted to determine the prevalence of prevalence of plasmodium (P) species, seasonal pattern; sex and age specific pattern with special reference to pregnant women. Holistic management of malaria with antioxidant Vitamins A.C.E'. In animal model was employed. Gnotobiotically reared male Swiss albino mice were inoculated with a standard dose of p. berghei, about 107 parasitized erythrocytes through intraperitoneal route. Treatment was administered according to body weight of mouse through intraperitoneal route, observing the lethal dose of Vitamins through the route. The blood was evaluated parasitologically. Plasmodium species encountered in patients showed significant difference (P < 0.05) in the distribution P. malariae, P. falciparum. For seasonal pattern, 830 (67.9 percent) was recorded coincide with rainy seasons while. 390 (50.1 percent) was recorded in dry seasons. A prevalence of 880 (88.0 percent) was recorded in males and 340 (34.0--percent) in females. Prevalence by gestational age in pregnant women showed 27 (9.6. percent) in second trimester and 80 (20.5 percent) in the trimester. There was a highly significant decrease (p < 0.0001) in parasitaemia, consequent to total clearance in all mice treated with antioxidant vitamin. A hundred (100 percent) mortality was recorded in positive untreated control group. Post mortem examinations revealed haemorrhagic lesions at the lower part of the brain. There was an effective treatment by orthomolecular approach.

Keywords: Mean White Blood Counts; Malaria Infected Mice; Antioxidants

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Citation: Esimai Bessie Nonyelum., et al. “Studies on Mean White Blood Counts in Malaria Infected Mice Treated with Antioxidants”. EC Emergency Medicine and Critical Care 4.8 (2020): 61-67.

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