Mini Review
Volume 4 Issue 6 - 2020
Graves’ Disease: Analytical Methods to Determine Antithyroid Therapeutic Agents in Biological Fluids
Chika J Mbah*
Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
*Corresponding Author: Chika J Mbah, Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.
Received: May 17, 2020; Published: May 25, 2020




Abstract

Graves’ disease is an autoimmune disease arising from antibodies that attach to receptors on thyroid hormone-producing cells in the thyroid gland triggering off over production of thyroid hormone. The most important diagnostic tests for Graves’ disease are measurements of serum levels of anti-TSH-receptor antibodies (TRAb) and thyroid ultrasonography. Clinical management of the disease involves the use antithyroid drugs, which mainly inhibit synthesis of thyroid hormone, or ablative treatments (iodine 131-radiotherapy or thyroidectomy) that remove or reduce thyroid tissue. Though these treatments do not target the disease process, however new agents blocking the thyrotropin and insulin-like growth factor receptors are under evaluation in preclinical or clinical studies for such purpose. Of all the analytical methods such as spectroscopy, electrochemical, electrophoresis and chromatography that have been used to determine antithyroid therapeutic agents (drugs) in biological fluids, high performance liquid chromatography seems to be the analytical method of choice.

Keywords: Graves’ Disease; Antithyroid Drugs; Biological Fluids; Analytical Methods

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Citation: Chika J Mbah. “Graves’ Disease: Analytical Methods to Determine Antithyroid Therapeutic Agents in Biological Fluids”. EC Emergency Medicine and Critical Care 4.6 (2020): 119-124.

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