Literature Review
Volume 4 Issue 6 - 2020
Compare Thiopental and Propofol Effect on Neonatal and Maternal Outcomes after Caesarean Section: A Non-Systematic Review
Nkola Ndomba Jean Claude
Department of Anaesthesia, Rundu Intermediate Referral Hospital, Namibia
*Corresponding Author: Nkola Ndomba Jean Claude, Department of Anaesthesia, Rundu Intermediate Referral Hospital, Namibia.
Received: March 07, 2020; Published: May 09, 2020


Background: Current study in obstetric anaesthesia recommends caesarean section to perform under neuraxial anaesthesia either spinal or epidural anaesthesia, but some conditions contraindicate neuraxial anaesthesia, and general anaesthesia is an alternative choice for these conditions. Thiopental 4 - 5 mg/kg and Propofol 2 mg/kg are used for general anaesthesia induction during caesarean section.

Methods: The study articles from 1989 up to 2016 comparing thiopental to Propofol in caesarean section have been reviewed.

Result: About 20 published articles and abstracts from 1989 up to 2016 were reviewed, these articles show that Propofol was an alternative induction agent for general anaesthesia in caesarean section and have few disadvantages on Apgar score of the neonate at one minute.

Conclusion: The reviewed articles show that Propofol is currently the most commonly used as induction drug for general anaesthesia and have good maternal and neonatal outcomes post caesarean section compare to thiopental.

Keywords: Propofol; Obstetric Anaesthesia; Thiopental; Caesarean Section


  1. Rob Dyer. “Update on general anaesthesia for C/S”. Southern African Journal of Anaesthesia and Analgesia 1 (2011).
  2. Up to date on use of Propofol and thiopental (2016).
  3. , et al. “Effect of Propofol versus thiopental on Apgar scores in new-borns and peri-operative outcomes of women undergoing emergency caesarean section: a randomized clinical trial”. BMC Anesthesiology 15 (2015): 63.
  4. , et al. “The pregnant patient: assessment and perioperative management”. Anesthesiology Clinics 34.1 (2016): 213-222.
  5. Mamidi M and Shiva Prasad D. “Propofol and Thiopentone as induction agents in Obstetric anesthesia - A comparative study”. IAIM4 (2016): 111-117.
  6. , et al. “Comparison of the effect of thiopental sodium and Propofol on haemodynamic, awareness and new-borns during caesarean section under general anaesthesia”. Turkish Journal of Anaesthesiology and Reanimation 43.2 (2015): 106-112.
  7. Dadras MM., et al. “Comparing propofol with sodium thiopental on neonatal Apgar score after elective cesarean section”. Zahedan Journal of Research in Medical Sciences 4 (2013): 21-24.
  8. Arzu Mercan., et al. “A prospective, randomized comparison of the effects of thiopental and Propofol on bispectral index during caesarean section till delivery of new-born”. Middle East Journal of Anesthesiology 5 (2012): 699-704.
  9. Mahjoobifard M., et al. “The comparison of propofol with thiopental as induction drug on neonatal Apgar during elective cesarean section”. Zahedan Journal of Research in Medical Sciences 4 (2011): 35-39.
  10. Perisa Golfam., et al. “The effect of Propofol and thiopental on Apgar score during caesarean section” (2009).
  11. Celleno D., et al. “Which induction drug for cesarean section? A comparison of thiopental sodium, propofol, and midazolam”. Journal of Clinical Anesthesia 4 (1993): 284-288.
  12. M Valtonen., et al. “Comparison of propofol and thiopentone for induction of anaesthesia for elective Caesarean section”. Anaesthesia9 (1989): 758-762.
  13. Sneyd JR. “Recent advances in intravenous anaesthesia”. British Journal of Anaesthesia5 (2004): 725-736.
  14. South African guidelines for safe use of procedural sedation and analgesia for diagnostic and therapeutic procedures in adults (2010).
  15. Tom Lupton., et al. “Tutorial on: Intravenous drugs used for the induction of anaesthesia”. Update in Anaesthesia.
  16. Michael A., et al. “Propofol infusion for cesarean section”. Canadian Journal of Anesthesia5 (1990): 514-520.
  17. Tiffany Sun Moon and Joshua Sappenfield. “Anesthesia management and challenges in the pregnant patient”. Current Anesthesiology Reports 6 (2016): 89-94.
Citation: Nkola Ndomba Jean Claude. “Compare Thiopental and Propofol Effect on Neonatal and Maternal Outcomes after Caesarean Section: A Non-Systematic Review”. EC Emergency Medicine and Critical Care 4.6 (2020): 62-73.

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