Research Article
Volume 4 Issue 67- 2020
Gorham-Stout Disease: Vanishing Bone Disease
Sonia Shahid1*, Tanzeem H2, Khan R3, Khan J3, Ahmed Khan H4, Bhan A5 and Kamal K6
1Department of Pediatrics, Karachi Medical and Dental College, Pakistan
2Department of Internal Medicine, Dow Medical College, Pakistan
3Department of Internal Medicine, Deccan College of Medical Sciences, India
4Department of Pediatrics, Dow International Medical College, Pakistan
5Department of Internal Medicine, Indira Gandhi Medical College, India
6Department of Pediatrics, Beaumont Hospital, Dearborn MI, USA
*Corresponding Author: Sonia Shahid, Department of Pediatrics, Karachi Medical and Dental College, Pakistan.
Received: March 14, 2020; Published: June 25, 2020




Abstract

Gorham-Stout disease is an extremely rare non-hereditary condition in which spontaneous, progressive resorption of bone occurs. It has no age, sex or racial predisposition. Because of its low incidence and variability in clinical presentation, the diagnosis is apparently missed. Moreover, there is no protocol or specific guidelines for the treatment. We present the data of patients less than 27-year-old, diagnosed with Gorham-Stout syndrome out of which most of them are with involvement of the left mandible, and discussed symptoms, diagnostic and therapeutic features. Diagnosis of this disease is critical and requires extensive workup and investigations with a combination of clinical, blood tests, radiological and histopathological findings. Surgical biopsy with histological identification of the vascular or lymphatic proliferation within the affected bone is an essential. As it has serious morbidity, it should be ruled out in every osteolytic bone condition. The first case of GSD in maxillofacial region was reported by Romer in 1924, Handbuch der speziellen pathologischen Anatomie and histology, Springer, Berlin. Since then, there have been few case reports and reviews of the same maxillofacial region. We present cases of GSD in maxillofacial region reported in literature along with our experience of cases.

Keywords: Gorham-Stout Syndrome; Acute Osteolysis; Mandible; Diagnosis; Antivirals Use

Citation: Sonia Shahid., et al. “Gorham-Stout Disease: Vanishing Bone Disease”. EC Emergency Medicine and Critical Care 4.7 (2020): 53-56.

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