Review Article
Volume 4 Issue 3 - 2020
Chikungunya Virus (CHIKV) Infection and the Protective Immunity: A Narrative Review
Rashed Noor* and Syeda Muntaka Maniha
School of Life Sciences (SLS), Independent University, Bangladesh (IUB), Bashundhara, Dhaka, Bangladesh
*Corresponding Author: Rashed Noor, Associate Professor of Microbiology, School of Life Sciences (SLS), Independent University, Bangladesh (IUB), Bashundhara, Dhaka, Bangladesh.
Received: January 27, 2020; Published: February 19, 2020




Abstract

Chikungunya virus (CHIKV) has been well known for causing the epidemic disease outbreaks mainly streaming into inflammations like the severe joint pains. Re-emergence of chikungunya viruses around the world is one of the most important clinical issues. Like the dengue viruses (DENV), CHIKV can initiate the systemic infection caused by the vector Aedes mosquito bites. Propagation of the viral elements principally appears to cause arthralgia in a similar pattern like DENV- or Zika virus (ZIKV) infections. Like DENV infections, the morbidity and mortality rate due to CHIKV infection may be intense especially among the older people. Components of the innate immune system like the type I interferon along with the CHIKV specific immunoglobulins are known to impart enduring immunity to CHIKV while they may also exert the immunopathologic role in the CHIKV pathogenesis. Indeed, the infection with CHIKV triggers the release of an array of cytokines and chemokines which in turn generate anti-viral response. Current review further pointed on the immune strategies exerted by the hosts against the CHIKV elements. Besides, the generation of both the innate immunity and the adaptive immunity at the early- and late stage of CHIKV infections is discussed together with the presentation of new models.

Keywords: Re-Emerging Infection; Chikungunya Virus (CHIKV); Immunity; Anti-Viral Response

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Citation: Rashed Noor and Syeda Muntaka Maniha. “Chikungunya Virus (CHIKV) Infection and the Protective Immunity: A Narrative Review”. EC Emergency Medicine and Critical Care 4.3 (2020): 01-10.

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