Abstract
Advances in cancer therapy or diagnosis are offered by immunotherapy, there are several approaches of immune therapy to counter cancer. Conventional cancer chemotherapy relied, killing the cancer cells by cytotoxic drugs. Due to toxic effects of the drugs on the patient and also the drug induced cancer with variety of adverse drug reactions. The cancer therapy was much faired. The quality of life of patients and high economic cost of drugs was very much discouraging for the patients. The new therapy in which immune system is applied no such side effects and new drug induced cancers that are not observed. The immune therapy can be described as utilizing owns immune system to counter the cancer. The immune therapy has several streams of treatments such as checkpoint inhibitors, adoptive cell transfer, monoclonal antibodies, vaccines for the treatment of cancer. In this article we are discussing chimeric antigen receptor T cell therapy with other immune therapy.
Keywords: CAR-T Therapy; Immunotherapy; Adoptive T-Cells Therapy; TCR Therapy
References
- Han X., et al. “Chimeric antigen receptor modified T-cells for cancer treatment”. Chronic Diseases and Translational Medicine 4.4 (2018): 225-243.
- Wang Z., et al. “New development in CAR-T cell therapy”. Journal of Hematology and Oncology 10 (2017): 53.
- Wu Y., et al. “The efficacy of chimeric antigen receptor (CAR) immunotherapy in animal models for solid tumors: A systematic review and meta-analysis”. PLoS One 12.11 (2017): 0187902.
- Riaz IB., et al. “Anti-CD 19 and anti-CD 20 CAR-modified T cells for B-cell malignancies: a systematic review and meta-analysis”. Immunotherapy 9.12 (2017): 979-993.
- Wei G., et al. “Advances of CD19-directed chimeric antigen receptor-modified T cells in refractory/relapsed acute lymphoblastic leukemia”. Experimental Hematology and Oncology 5 (2017): 10.
- Wang Y., et al. “Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T cells”. Journal of Clinical Immunology 155 (2014): 160-175.
- Mirzaei HR., et al. “Chimeric antigen receptors T cell therapy in solid tumor: challenges and clinical applications”. Frontiers in Immunology 8 (2017): 1850.
- Valton J., et al. “A Multidrug-resistant Engineered CAR-T cell for allogeneic combination immunotherapy”. Molecular Therapy 23 (2015): 1507-1518.
- Liu KY., et al. “Retargeted human avidin-CAR-T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging”. Oncotarget 6 (2015): 23735-23747.
- Zeming Mo., et al. “The Multi-Purpose Tool of Tumor Immunotherapy: Gene-Engineered T Cells”. Journal of Cancer 8.9 (2017): 1690-1703.
- Golubovskaya V and Wu L. “Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy”. Cancers (Basel) 8.3 (2015): 36.
- John K Lee., et al. “Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate”. Ccancer 115.19 (2018): E4473-E4482.
- Marybeth SY., et al. “Transfer of a TCR Gene Derived from a Patient with a Marked Antitumor Response Conveys Highly Active T-Cell Effector Functions”. Human Gene Therapy 16 (2005): 457-72.
- Scholten KB., et al. “Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer”. Journal of Translational Medicine 9 (2011): 147.
- Gehring AJ., et al. “Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines”. Journal of Hepatology 55 (2011): 103-110.
- Torikai H., et al. “Toward eliminating HLA class I expression to generate universal cells from allogeneic donors”. Blood 122 (2013): 1341-1349.
- Li H., et al. “The miR-17-92 cluster as a potential biomarker for the early diagnosis of gastric cancer: evidence and literature review”. Oncotarget (2017).
- Cho S., et al. “miR-23 approximately 27 approximately 24 clusters control effector T cell differentiation and function”. Journal of Experimental Medicine 213 (2016): 235-249.
- Sadegh-Nasseri S., et al. “Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy”. Immunology 129.1 (2010): 1-7.
- Challice L Bonifant., et al. “Toxicity and management in CAR-T-cell therapy”. Molecular Therapy Oncolytics 3 (2016): 16011.
Journal Menu
PubMed Indexed Article
EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.
PMID: 31143884 [PubMed]
PMCID: PMC6536005
EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.
PMID: 31565701 [PubMed]
PMCID: PMC6764777
EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.
PMID: 27747317 [PubMed]
PMCID: PMC5065347
EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?
PMID: 31460519 [PubMed]
PMCID: PMC6711478
EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?
PMID: 30215059 [PubMed]
PMCID: PMC6133253
EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.
PMID: 30417173 [PubMed]
PMCID: PMC6226033
EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.
PMID: 30264037 [PubMed]
PMCID: PMC6155992
EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.
PMID: 30198026 [PubMed]
PMCID: PMC6124505
EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.
PMID: 30294723 [PubMed]
PMCID: PMC6169793
EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs
PMID: 29285526 [PubMed]
PMCID: PMC5743211
EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique
PMID: 29911204 [PubMed]
PMCID: PMC5999047
EC Microbiology
Macrophages and the Viral Dissemination Super Highway
PMID: 26949751 [PubMed]
PMCID: PMC4774560
EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.
PMID: 27390782 [PubMed]
PMCID: PMC4933318
EC Microbiology
Reactive Oxygen Species in HIV Infection
PMID: 28580453 [PubMed]
PMCID: PMC5450819
EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population
PMID: 26280024 [PubMed]
PMCID: PMC4533840
EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis
PMID: 28066845 [PubMed]
PMCID: PMC5214344
EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology
PMID: 28936490 [PubMed]
PMCID: PMC5604476
EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia
PMID: 28713879 [PubMed]
PMCID: PMC5510658
EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature
PMID: 28133641 [PubMed]
PMCID: PMC5267489
EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling
PMID: 29333536 [PubMed]
PMCID: PMC5766278
EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.
PMID: 31032493 [PubMed]
PMCID: PMC6483108
EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.
PMID: 30957099 [PubMed]
PMCID: PMC6448571
EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.
PMID: 30101228 [PubMed]
PMCID: PMC6086333
EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.
PMID: 31080964 [PubMed]
PMCID: PMC6508883
EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.
PMID: 31093608 [PubMed]
PMCID: PMC6513001
EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.
PMID: 31552397 [PubMed]
PMCID: PMC6758937
EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.
PMID: 31681909 [PubMed]
PMCID: PMC6824723
EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.
PMID: 31681910 [PubMed]
PMCID: PMC6824726
EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.
PMID: 31528859 [PubMed]
PMCID: PMC6746603
EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?
PMID: 31276119 [PubMed]
PMCID: PMC6604646
EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.
PMID: 31406965 [PubMed]
PMCID: PMC6690616
EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.
PMID: 31517314 [PubMed]
PMCID: PMC6741290
EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.
PMID: 31633124 [PubMed]
PMCID: PMC6800226
EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.
PMID: 29662969 [PubMed]
PMCID: PMC5898812
EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.
PMID: 30215058 [PubMed]
PMCID: PMC6133268
News and Events
August Issue Release
We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the August issue of respective journals and the latest articles can be viewed on the current issue pages.
Submission Deadline for Upcoming Issue
ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before August 18, 2022.
Certificate of Publication
ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.
Best Article of the Issue
Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.
Certifying for Review
ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.
Latest Articles
The latest articles will be updated immediately on the articles in press page of the respective journals.