Research Article
Volume 4 Issue 3 - 2020
Heterogeneous Defects of Platelet Count and Responses to Agonists among Sudanese Patients with Hematological Malignancies
Ehab Mohammed Elmadinah Mohammed Ahmed1,4*, Fathelrahman M Hassan2, Babiker A Mohammed3, Mosab Nouraldein Mohammed Hamad4,5 and Sahar Eldirderi Gafar Osman4
1Faculty of Medical Laboratory Sciences, Dongola University, Sudan
2College of Applied Medical Science, Imam Abdulrahman Bin Fisal University, Saudi Arabia
3Sudanese Specialized Medical Commission, Sudan
4Medical Laboratory Science Department, Elsheikh Abdallah Elbadri University, Sudan
5Medical Laboratory Department, Alfajr College for Sciences and Technology, Sudan
*Corresponding Author: Ehab Mohammed Elmadinah Mohammed Ahmed, Faculty of Medical Laboratory Sciences, Dongola University, Sudan.
Received: January 17, 2020; Published: February 10, 2020




Abstract

Background: Abnormal platelet activation and an increased risk of thrombosis are frequent findings in cancer. 

Objectives: The aim of this study was to determine the heterogeneous defects of platelet count and responses to agonists among the major Sudanese hematological malignancies patients. 

Materials and Method: This study was done in Radiation & Isotopes Center Khartoum (RICK) during the period of February 2009 to October 2013. Two hundred and two (202) hospitalized and out patients who were diagnosed of having hematological malignancies in different age groups on treatment or off treatment against fifty (50) apparently healthy (male and female) as a control group. platelet count, platelet aggregation and D-Dimer test were done for both study groups and control.

Result: The results indicated that, significantly low platelet counts in AML, CLL (P < 0.05), and increased in CML (P < 0.05) and CGL (P < 0.05) in related to control group, and the Study of platelet aggregation in response to ADP, Collagen, and Epinephrine agonists was decreased in ALL, AML and MM, and in variable in CML and NHL and increased in CLL and HL. The positive D-Dimer was seen in 161 (79.7%) while 41 (20.3%) patients had negative D- Dimer results.

Conclusion: Markers of platelet defect were clearly observed in hematological malignancies patients, also indication of coagulation activation were confirmed. Some alterations in hemostasis and thrombotic events have frequently been observed in hematological malignancies patients. These hemostatic changes may contribute to a thrombotic and bleeding tendency in these patients.

Keywords: Cancer; Hematological Malignancies; Coagulation; Platelets Aggregation

References

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Citation: Ehab Mohammed Elmadinah Mohammed Ahmed., et al. “Heterogeneous Defects of Platelet Count and Responses to Agonists among Sudanese Patients with Hematological Malignancies”. EC Emergency Medicine and Critical Care 4.3 (2020): 01-08.

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