Research Article
Volume 4 Issue 3 - 2020
The Efficiency of Alternative Method for Stomach Pain When Patients Took Salt and Water Without Using Medications
Milorad Paunović*
University of Belgrade, Clinical Center of Serbia, Belgrade, Serbia
*Corresponding Author: Milorad Paunović, University of Belgrade, Clinical Center of Serbia, Belgrade, Serbia.
Received: December 30, 2019; Published: February 08, 2020


In this paper we analyzed the impact of using of water and salt like а helpful in improving the symptoms of stomach pain. 416 patients (male, 74.1%; mean, 41.7 years old) with stomach pain were randomly allocated to two groups. For six weeks, investigated group of patients, 208 patients ingested at least 2 liters per day of water and 1 gram of salt, while the control group of patents, 208 patients ingested only water. Stomach pain scores (quality-of-life, abdominal pain/discomfort) were assessed before and after treatment via questionnaires. In our investigations exist statistically significant correlation between stomach pain and using of salt and water like a therapy for stomach pain (c2=1.981; p>0.05). 200 patients with salt and water therapy did not have stomach pain one hour after therapy or 96.2% and 189 patients who took only water, had stomach pain and one hour after therapy with water every time in six weeks or 90.9%. In our research exist a statistically significant relationship between stomach pain after therapy with salt and water and male gender (c2=31.482; p<0.01). Of the total 8 patients with stomach pain after using therapy with salt and water, 6 patients were male or 72.5%, while only 2 patients were female or 27.5%.

Keywords: Alternative Method; Functional Dyspepsia; Stomach Pain; Therapy with Salt and Water


  1. Baron JH., et al. “Three centuries of stomach symptoms in Scotland”. Alimentary Pharmacology and Therapeutics 24 (2006): 821-829.
  2. Hare E. “The history of ‘nervous disorders’ from 1600 to 1840, and a comparison with modern views”. British Journal of Psychiatry 159 (1991): 37-45.
  3. Jones RH. “Approaches to uninvestigated dyspepsia”. Gut 50.4 (2002): 42-46.
  4. Collen MJ and Loebenberg MJ. “Basal gastric acid secretion in nonulcer dyspepsia with or without duodenitis”. Digestive Diseases and Sciences 34 (1989): 246-250.
  5. Simren M., et al. “Acid infusion enhances duodenal mechanosensitivity in healthy subjects”. American Journal of Physiology-Gastrointestinal and Liver Physiology 285 (2003): 309-315.
  6. O’Morain C. “Role of Helicobacter pylori in functional dyspepsia”. World Journal of Gastroenterology 12 (2006): 2677-2680.
  7. Sarnelli G., et al. “Symptom patterns and pathophysiological mechanisms in dyspeptic patients with and without Helicobacter pylori”. Digestive Diseases and Sciences 48 (2003): 2229-2236 .
  8. Rhee PL., et al. “Lack of association of Helicobacter pylori infection with gastric hypersensitivity or delayed gastric emptying in functional dyspepsia”. American Journal of Gastroenterology 94 (1999): 3165-3169.
  9. C Canavan., et al. “The epidemiology of irritable bowel syndrome”. Journal of Clinical Epidemiology 6 (2014): 71-80.
  10. K Whelan., et al. “The low FODMAP diet in the management of irritable bowel syndrome: an evidence-based review of FODMAP restriction, reintroduction and personalisation in clinical practice”. Journal of Human Nutrition and Dietetics 31.2 (2018): 239-255.
  11. P Moayyedi., et al. “Irritable bowel syndrome diagnosis and management: A simplified algorithm for clinical practice”. United European Gastroenterology Journal 5.6 (2017): 773-788.
  12. A Harper., et al. “The Role of Bacteria, Probiotics and Diet in Irritable Bowel Syndrome”. Foods 7 (2018): 2-13.
  13. LA Harris and N Baffy. “Modulation of the gut microbiota: a focus on treatments for irritable bowel syndrome”. Postgraduate Medical Journal 129 (2017): 872-888.
  14. G Gasbarrini., et al. “Evaluation of thermal water in patients with functional dyspepsia and irritable bowel syndrome accompanying constipation”. World Journal of Gastroenterology 12.16 (2006): 2556-2562.
  15. JA Koufman and N Johnston. “Potential bene fits of pH 8.8 alkaline drinking water as an adjunct in the treatment of reflux disease”. Annals of Otology, Rhinology and Laryngology 121.7 (2012): 431-434.
  16. R Nassini., et al. “A bicarbonate-alkaline mineral water protects from ethanol-induced hemorrhagic gastric lesions in mice”. Biological and Pharmaceutical Bulletin 33.8 (2010): 1319-1323.
  17. M Bertoni., et al. “Effects of a bicarbonate-alkaline mineral water on gastric functions and functional dyspepsia: A preclinical and clinical study”. Pharmacological Research 46.6 (2002): 525-531.
  18. DW Shin., et al. “Effect s of Alkaline-Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double-Blind, Placebo-Controlled Pilot Study”. Evidence-Based Complementary and Alternative Medicine 1.2 (2018): 1-8.
  19. H Miwa., et al. “Generation of dyspeptic symptoms by direct acid infusion into the stomach of healthy Japanese subjects”. Alimentary Pharmacology and Therapeutics 26.2 (2007): 257-264.
  20. M Ishii., et al. “Duodenal hypersensitivity to acid in patients with functional dyspepsia-pathogenesis and evaluation”. Journal of Smooth Muscle Research 46.1 (2010): 1-8.
  21. M Nakata-Fukuda., et al. “Inhibitory effect of the selective serotonin 5-HT3 receptor antagonist ramosetron on duodenal acidification-induced gastric hypersensitivity in rats”. European Journal of Pharmacology 31 (2014): 88-92.
  22. D Gelfond., et al. “Intestinal pH and gastrointestinal transit profiles in cystic fibrosis patients measured by wireless motility capsule”. Digestive Diseases and Sciences 58 (2013): 2275-2281.
  23. M Suzuki., et al. “Oral carbonation attenuates feeling of hunger and gastric myoelectrical activity in young women”. Journal of Nutritional Science and Vitaminology 63.3 (2017): 186-192.
  24. U Pohl., et al. “Pilot Trial on the Efficacy and Safety of a Natural Mineral Water Rich in Hydrogen Carbonate on Functional Dyspepsia and Heartburn”. Open Journal of Gastroenterology 6.3 (2016): 88-96.
  25. J Naumann., et al. “Effects of Sulfate-Rich Mineral Water on Functional Constipation: A Double-Blind, Randomized, Placebo-Controlled Study”. Forschende Komplementärmedizin 23.6 (2016): 356-363.
  26. R Cuomo., et al. “Effects of carbonated water on functional dyspepsia and constipation”. European Journal of Gastroenterology and Hepatology 14.9 (2002): 991-999.
  27. M Anti., et al. “Effects of mineral-water supplementation on gastric emptying of solids in patients with functional dyspepsia assessed with the 13C-octanoic-acid breath test”. Hepato-Gastroenterology 51.60 (2004): 1856-1859.
  28. RD Moloney. “Stress and the microbiota brain axis in visceral pain: relevance to irritable bowel syndrome”. CNS Neuroscience and Therapeutics 22.2 (2016): 102-117.
  29. Y Ringel and T Ringel-Kulka. “The intestinal microbiota and irritable bowel syndrome”. Journal of Clinical Gastroenterology 49 (2015): 56-59.
  30. M Grover., et al. “Postinfectious irritable bowel syndrome: Mechanisms related to pathogens”. Neurogastroenterology and Motility 26.2 (2014): 156-167.
  31. YE Joo. “Alteration of fecal microbiota in patients with postinfectious irritable bowel syndrome”. Journal of Neurogastroenterology and Motility 21 (2015): 135-137.
  32. IB Jeffery., et al. “An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota”. 61.7 (2012): 997-1006.
  33. HL Dupont. “Review article: Evidence for the role of gut microbiota in irritable bowel syndrome and its potential influence on therapeutic targets”. Alimentary Pharmacology and Therapeutics 39.10 (2014): 1033-1042.
Citation: Milorad Paunović. “The Efficiency of Alternative Method for Stomach Pain When Patients Took Salt and Water Without Using Medications”. EC Emergency Medicine and Critical Care 4.3 (2020): 01-06.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

October Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the October issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before November 01, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to