Research Article
Volume 6 Issue 1 - 2022
Antidiabetic and Antioxidant Activities of Ethanolic Extract of Anogeissus leiocarpus in Alloxan-Induced Type 1 Diabetes Mellitus in Wistar Rats
Sabina Mbafan Num-Adom1,2, Sani Adamu1, Tagang Aluwong3, Ngozi Ejum Ogbuagu3, Ismaila Alhaji Umar4 and King Akpofure Nelson Esievo1*
1Department of Veterinary Pathology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
2Department of Veterinary Pathology, College of Veterinary Medicine, University of Agriculture, Makurdi, Benue State, Nigeria
3Department of Veterinary Physiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
4Department of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Nigeria
*Corresponding Author: King Akpofure Nelson Esievo, Department of Veterinary Pathology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
Received: June 16, 2022; Published: June 30, 2022




Abstract

Antidiabetic property of Anogeissus leiocarpus on hyperglycaemia-induced oxidative stress in spleen, kidney, heart, brain and liver. The study investigated antidiabetic and antioxidant effects of A. leiocarpus ethanolic extract in alloxan-induced diabetes mellitus and hyperglycaemia-induced oxidative stress in Wistar rats. Four groups of nine rats each; non-diabetic (ND), diabetic untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE) were assayed for fasting blood glucose and oxidative stress biomarkers. Blood glucose significantly (P < 0.001) increased, as well as oxidative stress biomarkers, malondialdehyde (MDA) (P < 0.05; 0.002; 0.001) and significant (P < 0.05) variations in superoxide dismutase (SOD), catalase and glutathione (GSH) in DU. Ethanolic extract of A. leiocarpus significantly (P < 0.001) reversed the blood glucose and the oxidative stress biomarker to normal in DE as in DI. A. leiocarpus can serve as non-conventional treatment for diabetes-induced oxidative stress.

Keywords: Antidiabetic; Antioxidant; Oxidative Stress; Anogeissus leiocarpus; Wistar Rats

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Citation: King Akpofure Nelson Esievo., et al. “Antidiabetic and Antioxidant Activities of Ethanolic Extract of Anogeissus leiocarpus in Alloxan-Induced Type 1 Diabetes Mellitus in Wistar Rats”. EC Diabetes and Metabolic Research 6.1 (2022): 38-49.

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