Research Article
Volume 6 Issue 1 - 2022
Incidence of Renal Nephropathy after Kidney Transplantation in Patients with or without Pre-Transplant Type II Diabetes
Mahmoud Mansour1*, Sultan Alanazi1, Mohammad Alenazi1, Alhomaidi Alghuwairy1, Nataleen A. Albekairy2, Yousef Al-Rajhi3, Abdulmalik Alkatheri1, Shmeylan Al-Harbi1 and Abdulkareem M Albekairy1
1College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
2College of Medicine,, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
3Pharmaceutical Care Department, King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, KSA
*Corresponding Author: Mahmoud Mansour, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Received: May 23, 2022; Published: June 29, 2022




Abstract

Objectives: A remarkable improvement of impaired patient’s kidney function is often observed after renal transplantation. long-term renal allograft survival is ensured on preserving improved kidney function. However, there are different risk factors; one of the major risk factor is diabetic nephropathy (DN). Therefore, the goal of the present study was to predict incidence of diabetic nephropathy after kidney transplantation within the first 8 months.

Methods: To investigate the incidence of diabetic nephropathy after renal transplantation in patients with or without type 2 diabetes, a retrospective analyzed study was performed on fifty-two renal transplant patients, 33 with type 2 diabetes pre-transplant and 19 non-diabetic, they underwent kidney transplantation in 2009 to 2019 in King Abdulaziz Medical City- National Guard and were evaluated consecutively for 8-month before incidence of nephropathy and up to 8 months’ post-nephropathy. Time course of changes in kidney functions as, measurements of serum creatinine (Scr), blood urea nitrogen (BUN), microalbuminuria, were recorded before and after incidence of different nephropathy. Estimated glomerular filtration rate (eGFR) was also reported. In addition, age, anthropometric factors and causes of DN were analyzed.

Results: There were no significant difference in all investigated parameters 8 months before and 8 months after incidence of different types of nephropathy as (IgA, Diabetic, Glomerular and others) based on monthly assessment. However, the incidence of nephropathy in post-transplanted non-diabetic patients are associated with a remarkable higher level of serum creatinine, BUN and microalbuminuria and reduction in eGFR starting from first month as compared with non-diabetic without nephropathy. While a profound elevation of serum creatinine and BUN in month 2 and 5 respectively and significant lowering in GFR in month 6 were associated with the incidence of nephropathy in diabetic post-transplant kidney as compared with diabetic non-nephropathy post-transplant patients. Comparing incidence of nephropathy in post-transplant diabetic and non-diabetic patients, serum creatinine started to increase significantly from month 5 while others parameters were kept elevated but non-significant. However, all tested parameters were kept in normal ranges between post-transplant diabetic and non-diabetic patients without nephropathy.

Conclusion: In non-diabetic patients, a consistent significant elevation of serum creatinine, BUN and microalbuminuria and reduction in eGFR starting from first month were associated with incidence of nephropathy in post-transplanted kidney. While in diabetic patients a significant elevation of serum creatinine was noticed in month 2. The clinical use of eGFR and serum creatinine may aid in predicting incidence of early diabetic nephropathy.

 

Keywords: Incidence of Renal Nephropathy; Kidney Transplantation; Pre-Transplant Type II Diabetes

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Citation: Mahmoud Mansour., et al. “Incidence of Renal Nephropathy after Kidney Transplantation in Patients with or without Pre-Transplant Type II Diabetes”. EC Diabetes and Metabolic Research 6.1 (2022): 01-16.

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