Review Article
Volume 5 Issue 3 - 2021
Why Indians More Susceptible to Diabetes?
Bigoniya Papiya1* and Jagriti Bigoniya2
1DSKM College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh, India
2JSS College of Pharmacy, Sri Shivarathreeshwara Nagara, Mysore, Karnataka, India
*Corresponding Author: Papiya Bigoniya, Principal, DSKM College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh, India.
Received: December 05, 2020; Published: January 30, 2021




Abstract

This review aims to investigate the facts behind the augmented susceptibility of the Indian population towards type 2 diabetes. The high rate prevalence of diabetes has been associated with rapid socioeconomic progress and urbanization in India. Epidemiology of diabetes prevalence reveals that the urban population is more vulnerable to diabetes due to risk factors like lifestyle changes, food habits, sedentary work, and high stress levels. These risk factors are equally responsible for obesity, diabetes, and cardiovascular disease globally. The key point is Indians are predisposed to insulin resistance, higher abdominal adiposity, waist circumference despite lower body mass index. The Indian population has low metabolic capacity and insulin resistance syndrome, which can be attributed to the low birth weight and less lean mass in adulthood. Some population-specific risk-alleles contribute to the elevated prevalence of diabetes in Indians, like the FTO (fat mass and obesity) gene, which is again environment-dependent, resulting in a much stronger relationship of obesity with diabetes among South Asians. Indians tend to have a larger waist and waist to hip ratio, excess body fat, and abdominal adiposity despite a moderate level of obesity, indicating the predisposition to diabetes at a younger age than in Europeans.

Keywords: Type 2 Diabetes; Epidemiology; Prevalence; Genetic Factors; Insulin Resistance; Obesity

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Citation: Bigoniya Papiya and Jagriti Bigoniya. “Why Indians More Susceptible to Diabetes?”. EC Diabetes and Metabolic Research 5.2 (2021): 26-32.

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