Editorial
Volume 5 Issue 2 - 2021
Obesity and Elevated Leptin Levels during SARS-COV-2 Infection
Carmine Finelli1,2*
1Department of Internal Medicine, Ospedale Cav. R. Apicella - ASL Napoli 3 Sud, Via di Massa, Pollena, Napoli, Italy
2Covid Hospital Boscotrecase - ASL Napoli 3 Sud, Via Lenza, Boscotrecase, Napoli, Italy
*Corresponding Author: Carmine Finelli, Department of Internal Medicine, Ospedale Cav. R. Apicella - ASL Napoli 3 Sud, Via di Massa, Pollena, Napoli, Italy.
Received: January 09, 2021; Published: January 30, 2021




Obesity is a risk factor for the development of respiratory failure in SARS-CoV-2 infected patients. Leptin generated in visceral fat can contribute in ventilation system decline [1,2]. Visceral fat, lung tissue and leptin development have an interlinking role. The path to further study and care will contribute to this knowledge [3]. Leptin is a pleiotropic protein mainly synthesized into the bloodstream from white adipose tissue and could be transferred through the blood-brain barrier. Leptin is a major regulator of energy homeostasis, metabolism, neuroendocrine and immune system activity, due to its effects on the central nervous system and peripheral tissues [4].

References

    1. Ribeiro MJ., et al. “High fat diet blunts the effects of leptin on ventilation and on carotid body activity”. The Journal of Physiology 15 (2018): 3187-3199.
    2. Finelli C. “A New Endocrine “Gland”: Adipose Tissue”. EC Endocrinology and Metabolic Research02 (2020): 07-09.
    3. Finelli C. “Visceral Fat and Diabetes: A Direct Relationship?”. EC Diabetes and Metabolic Research3 (2020): 01-02.
    4. Dornbush S and Aeddula NR. “Physiology, Leptin”. In: StatPearls. Treasure Island (FL): StatPearls (2020).
    5. Martínez-Sánchez N. “There and Back Again: Leptin Actions in White Adipose Tissue”. International Journal of Molecular Sciences 17 (2020): 6039.
    6. Pham DV., et al. “Autophagy activation and SREBP-1 induction contribute to fatty acid metabolic reprogramming by leptin in breast cancer cells”. Molecular Oncology (2020).
    7. Srinivasan G., et al. “Leptin receptor stimulation in late pregnant mouse uterine tissue inhibits spontaneous contractions by increasing NO and cGMP”. Cytokine 137 (2021): 155341.
    8. Pérez-Pérez A., et al. “Role of Leptin in Inflammation and Vice Versa”. International Journal of Molecular Sciences 16 (2020): 5887.
    9. Żelechowska P., et al. “The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview”. Obesity Reviews 10 (2020): e13055.
    10. Baranowska-Bik A and Bik W. “The Association of Obesity with Autoimmune Thyroiditis and Thyroid Function-Possible Mechanisms of Bilateral Interaction”. International Journal of Endocrinology (2020): 8894792.
    11. AlZaim I., et al. “Adipose Tissue Immunomodulation: A Novel Therapeutic Approach in Cardiovascular and Metabolic Diseases”. Frontiers in Cardiovascular Medicine 7 (2020): 602088.
    12. Chen JR., et al. “Acute Phase Serum Leptin, Adiponectin, Interleukin-6, and Visfatin Are Altered in Chinese Children With Febrile Seizures: A Cross-Sectional Study”. Frontiers in Endocrinology 11 (2020): 531.
    13. Han H and Zhou W. “Leptin and Its Derivatives: A Potential Target for Autoimmune Diseases”. Current Cancer Drug Targets 15 (2019): 1563-1571.
    14. Francisco V., et al. “Obesity, Fat Mass and Immune System: Role for Leptin”. Frontiers in Physiology 9 (2018): 640.
    15. Song J and Deng T. “The Adipocyte and Adaptive Immunity”. Frontiers in Immunology 11 (2020): 593058.
    16. Tan CL., et al. “PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance”. Journal of Experimental Medicine 1 (2021): e20182232.
    17. Zhao RX., et al. “Increased AHR Transcripts Correlate With Pro-inflammatory T-Helper Lymphocytes Polarization in Both Metabolically Healthy Obesity and Type 2 Diabetic Patients”. Frontiers in Immunology 11 (2020): 1644.
    18. La Cava A. “Leptin in inflammation and autoimmunity”. Cytokine 98 (2017): 51-58.
    19. Aydemir MN., et al. “Computationally predicted SARS-COV-2 encoded microRNAs target NFKB, JAK/STAT and TGFB signaling pathways”. Gene Reports 22 (2021): 101012.
    20. Patra T., et al. “SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells”. PLOS Pathogens 12 (2020): e1009128.
Citation: Carmine Finelli. “Obesity and Elevated Leptin Levels during SARS-COV-2 Infection”. EC Diabetes and Metabolic Research 5.2 (2021): 23-25.

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