Research Article
Volume 5 Issue 2 - 2021
Ultralong Analogue Insulin Degludec in Type 1 Diabetes: Reduction of Hypoglycemic Events
Lilian Sanhueza1*, Pilar Durruty2 and Manuel García de los Ríos3
1Associated Professor, Faculty of Medical Sciences, University of Santiago of Chile, Santiago, Chile
2Associated Professor, Faculty of Medicine, University of Chile, Santiago, Chile
3Titular Professor, Faculty of Medicine, University of Chile, Santiago, Chile
*Corresponding Author: Lilian Sanhueza, Associated Professor, Faculty of Medical Sciences University of Santiago of Chile, Santiago, Chile.
Received: December 16, 2020; Published: January 20, 2021




Abstract

Long-acting insulins analogues are related with the reduction of hypoglycemic events.

Objective: Ultralong-acting insulin analog Degludec (IDeg) in type 1 diabetic patients (T1D) previously treated with Glargine (U-100) with severes hypoglycemic events and poor metabolic control.

Patients and Method: 230 T1D patients were followed for 18 months, average 34 years old and 14 years of the diabetes diagnosed. Hypoglycemias, biochemical parameters and insulin requirements were analyzed in a period of 18 months. All the patients were on a basal bolus regimen with IDeg as basal adjusted fortnightly, and ultra-fast bolus insulin pre-meals three times a daily.

Results: At 3 months fasting glycemia decreased from 253 mg/dl to 180 mg/dl; at 6 months 156 mg/dl; at 12 months151 mg/dl and at 18 months 150 mg/dl. Glycated hemoglobin (HbA1c) initially 10.6%, decreased at 3 months to 8.7% at 6 months 8.3% at 12 months 9.0%, at 18 months 9.0%. All these results were statistically significant p < 0.05. Hypoglycemic events, milds, moderate, severes, and nocturnal, decreased significantly throughout the study, improving the quality of life of patients

Conclusion: IDeg in T1D showed to reduce fasting glycemia, HbA1c, and hypoglycemic events.

 Keywords: Clinical Parameters; Fasting Glycemia; Metabolic Control

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Citation: Lilian Sanhueza., et al. “Ultralong Analogue Insulin Degludec in Type 1 Diabetes: Reduction of Hypoglycemic Events”. EC Diabetes and Metabolic Research 5.2 (2021): 08-14.

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