Research Article
Volume 5 Issue 2 - 2021
Effect of Ziziphus vulgaris L. (Jujube) Powder and Extract on Liver Damage in STZ-Induced Diabetic Rats
Sedigheh Asgary1, Najmeh Goli-malekabadi1*, Bahman Rashidi2, Mahmood Rafieian Kopaei3 and Amirhossein Sahebkar4
1Isfahan Cardiovascular Research Institute, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2Department of Anatomical Sciences, School of Medicine Isfahan University of Medical Sciences, Isfahan, Iran
3Department of Pharmacology, School of Medicine and Herbal Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
4Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
*Corresponding Author: Najmeh Goli-malekabadi, Isfahan Cardiovascular Research Institute, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Received: February 16, 2021; Published: February 20, 2021


Purpose: Diabetes mellitus (DM) is a metabolic disorder arises as a result of deficient in production and secretion of insulin. Ziziphus vulgaris L. (jujube) is a medicinal plant used for the treatment of DM and liver diseases traditionally. The aim of the present study was to investigate the protective effects of jujube fruit on the liver changes due to DM.

Methods: Intra-peritoneal injection of 60 mg/kg bw streptozotocin (STZ) was using to DM induction in rats. Jujube fruit powder (1 g/ kg bw) and extract (1 g/kg bw) were administered for 2 weeks prior and 3 weeks after STZ injection. Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were determined.

Results: Serum AST levels were found to remain unaltered compared to pre-diabetic state following treatment with jujube powder but not jujube extract and powder showed a preventing effect on AST elevation. Whilst treatment with jujube powder or extract had no significant reduction on ALT and ALP levels. Also, histopathological examinations revealed a significant reduction in hepatic injury with both jujube preparations.

Conclusion: The present findings suggest a hepatoprotective role of jujube supplementation in particular in the powdered form against DM-induced liver damage.

Keywords: Ziziphus vulgaris; Diabetes Mellitus; Streptozotocin; Liver Enzymes


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Citation: Najmeh Goli-malekabadi., et al. “Effect of Ziziphus vulgaris L. (Jujube) Powder and Extract on Liver Damage in STZ-Induced Diabetic Rats”. EC Diabetes and Metabolic Research 5.2 (2021): 01-07.

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