Volume 4 Issue 12 - 2020
Steroidogenic Factor 1 (Sf-1) as Important Metabolic Regulators in the Ventromedial Nucleus of the Hypothalamus (Vmh)
Carmine Finelli1,2* and Simone Dal Sasso MBioTech3
1Department of Internal Medicine, Ospedale Cav. R. Apicella - ASL Napoli Sud, Via di Massa, Pollena (Napoli), Italy
2Covid Hospital Boscotrecase - ASL Napoli Sud, Via Lenza, Boscotrecase (Napoli), Italy
3Independent Researcher, Naples, Italy
*Corresponding Author: Carmine Finelli, Department of Internal Medicine, Ospedale Cav. R. Apicella - ASL Napoli Sud, Via di Massa, Pollena (Napoli) and Covid Hospital Boscotrecase - ASL Napoli Sud, Via Lenza, Boscotrecase (Napoli), Italy.
Received: December 03, 2020; Published: November 30, 2020

A nuclear receptor expressed in the adrenal glands, gonads, anterior pituitary, and ventromedial hypothalamus nucleus (VMH) is steroidogenic factor 1 (SF-1) [1]. Not only for the production of VMH, but also for its physiological functions, SF-1 is essential [2]. The VMH is a significant hypothalamic nucleus that is important for controlling feeding and preserving homeostasis of whole body resources. VMH lesions change feeding habits and are associated with hyperphagia and obesity development [3]. Likewise, VMH acts as a nutrient sensor and has been shown to respond to decreasing nutritional conditions such as hypoglycemia by inhibiting the development of insulin and by stimulating the release of glucagon and catecholamines [4]. The expression of leptin receptors in the VMH also indicates the importance of this nucleus in reacting to leptin-induced feeding, metabolism and control of energy balance [2].


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Citation: Carmine Finelli and Simone Dal Sasso MBioTech. “Steroidogenic Factor 1 (Sf-1) as Important Metabolic Regulators in the Ventromedial Nucleus of the Hypothalamus (Vmh)”. EC Diabetes and Metabolic Research 4.12 (2020): 11-13.

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