Volume 4 Issue 10 - 2020
Diabetes Mellitus in Ongoing Covid-19 Pandemic
Ajay Kumar Mishra*, Davendra Kumar, Mehboob Subhani Siddiqi, Fakree Ali Khan and Abhishek Chetal
Department of Internal Medicine, Era’s University/Era’s Lucknow Medical College, India
*Corresponding Author: Ajay Kumar Mishra, Department of Internal Medicine, Era’s University/Era’s Lucknow Medical College, India.
Received: September 04, 2020; Published: September 30, 2020

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing pandemic. As of now, more than 25 million confirmed cases including over 8 lakh death have been reported around the world.

Recent data suggest that most people with COVID-19 have comorbidities, among these the most prevalent of which are diabetes, cardiovascular disease, and hypertension [1]. Researchers have revealed that the endocrine and metabolic conditions are risk factors for acquiring the new coronavirus and care of these patients pose unique challenges in clinical management [2].


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  2. Rubino F., et al. “New-Onset Diabetes in Covid-19”. The New England Journal of Medicine 8 (2020): 789-790.
  3. Toniolo A., et al. “The diabetes pandemic and associated infections: suggestions for clinical microbiology”. Reviews in Medical Microbiology 30 (2019): 1-17.
  4. Bornstein SR., et al. “Practical recommendations for the management of diabetes in patients with COVID-19”. The Lancet Diabetes and Endocrinology 6 (2020): 546-550.
  5. Chee YJ., et al. “Diabetic ketoacidosis precipitated by Covid-19 in a patient with newly diagnosed diabetes mellitus”. Diabetes Research and Clinical Practice 164 (2020): 108166.
  6. Li J., et al. “COVID-19 infection may cause ketosis and ketoacidosis”. Diabetes, Obesity and Metabolism 20 (2020): 1-7.
  7. Ren H., et al. “Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19”. Cardiovascular Diabetology 1 (2020): 58.
  8. Remuzzi A and Remuzzi G. “COVID-19 and Italy: what next?” Lancet 395 (2020): 1225-1228.
  9. Geerlings SE and Hoepelman AIM. “Immune dysfunction in patients with diabetes mellitus (DM)”. FEMS Immunology and Medical Microbiology 3-4 (1999): 259-265.
  10. Pal R and Bhansali A. “COVID-19, diabetes mellitus and ACE2: the conundrum”. Diabetes Research and Clinical Practice 162 (2020): 108132.
  11. Maddaloni E and Buzzetti R. “Covid-19 and diabetes mellitus: unveiling the interaction of two pandemics”. Diabetes/Metabolism Research and Reviews (2020): e33213321.
  12. Mehta P., et al. “COVID- 19: consider cytokine storm syndromes and immunosuppression”. Lancet 395 (2020): 1033e4.
  13. Bindom SM and Lazartigues E. “The sweeter side of ACE2: physiological evidence for a role in diabetes”. Molecular and Cellular Endocrinology 302 (2009): 193-202.
  14. Roca-Ho H., et al. “Characterization of ACE and ACE2 expression within different organs of the NOD mouse”. International Journal of Molecular Sciences 18 (2017): e563.
  15. Yang JK., et al. “Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes”. Acta Diabetologica 47 (2010): 193-199.
  16. Harmer D., et al. “Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme”. FEBS Letters 532 (2002): 107-110.
  17. Yang JK., et al. “Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS”. Diabetic Medicine 6 (2006): 623-628.
  18. Zhu L., et al. “Association of blood glucose control and outcomes in patients with COVID-19 and pre-existing type 2 diabetes”. Cell Metabolism 6 (2020): 1068-1077.
  19. https://www.england.nhs.uk/wp-content/uploads/2020/05/Valabhji-COVID-19-and-Diabetes-Paper-2-Full-Manuscript.pdf
  20. Fang L., et al. “Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?” The Lancet Respiratory Medicine 4 (2020): e21.
  21. De Simone G. “ESC Council on Hypertension. Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angiotensin Receptor Blockers”. European Society of Cardiology (2020).
  22. Hartmann-Boyce J., et al. “Managing diabetes during the COVID-19 epidemic” (2020).
Citation: Ajay Kumar Mishra., et al. “Diabetes Mellitus in Ongoing Covid-19 Pandemic”. EC Diabetes and Metabolic Research 4.10 (2020): 15-17.

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